Cancer Therapies That May Be Ineffective—or Harmful - Part 2
Choose your Healer Carefully
Paul Marik
Metabolic treatment of cancer and other disorders
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Unproven Cancer Treatments: Separating Hope From Evidence - Part 1
Choose your Healer Carefully
Cancer Is Not Defeated by a Single Target: Why Metabolic Flexibility Demands Multi-Target Therapy
Cancer Is Not Defeated by a Single Target: Why Metabolic Flexibility Demands Multi-Target Therapy
MYC: The Master Driver of Cancer Growth
Among the thousands of genes implicated in cancer, few have had as profound an impact as MYC. Unlike many oncogenes that drive a limited number of tumors, MYC acts as a universal amplifier of malignant behavior. It regulates cellular proliferation, metabolism, protein synthesis, mitochondrial function, stemness, angiogenesis, immune evasion, and genomic instability. Estimates suggest that…
TP53: The Guardian of the Genome
Why the World's Most Important Tumor Suppressor Does Far More Than Prevent DNA Mutations
APC and the Origins of Colorectal Cancer
How One Broken Gene Opens the Door to Cancer
EGFR: The First Great Targeted Therapy
How a Single Mutation Changed the Way We Think About Cancer
What is the KRAS Mutation – and Why does it Matter?
A KRAS G12V mutation is one of the most common activating mutations in the KRAS oncogene. It results from a single amino acid substitution in which glycine (G) at codon 12 is replaced by valine (V). This seemingly small change has profound biological consequences because it locks the KRAS protein into an “on” state, continuously stimulating pathways that drive cancer cell growth, survival,…
Understanding the BRAF Mutation: One of Oncology’s Biggest Success Stories
The BRAF mutation is one of the best-characterized cancer-driving (oncogenic) mutations.
BRCA1 and BRCA2: Beyond Breast Cancer
Why These Mutations Are Really About DNA Repair, Genomic Stability, and Precision Oncology
Which Comes First: Driver Mutations or the Warburg Effect?
This question lies at the heart of one of the most important debates in modern cancer biology.