Medical peer-review journal for practitioners and researchers. Issues quarterly . Editor-in-Cheif : Olga V. Khlynova, MD, PhD, professor, Corresponding Member of the Russian Academy of Sciences Indexing : Higher Attestation Commission (VAK), RUS White List, Russian Science Citation Index, Scopus, CNKI, HEP Journals, Lens, OpenAlex, Scilit, Google Scholar, Ulrich's Periodical Directory, Dimensions. Publishes from 1923 in Perm (Russia). ISSN 0136-1449 (Print), ISSN 2687-1408 (Online)
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This article explores the life of the renowned Russian surgeon Vyacheslav Mikhailovich Subbotin (1940–2025). He graduated from the Perm Medical Institute and then completed postgraduate studies at the Moscow Research Institute of Clinical and Experimental Surgery. In 1969, he defended his PhD dissertation in Moscow on "Anatomical, Experimental, and Clinical Materials on Tracheal Surgery." He…
This article is dedicated to Professor Pavel Ivanovich Pichugin—an outstanding pediatrician, scientist, educator, public figure, head of the Department of Pediatric Diseases, and founder of the first Children's Clinic in the Western Urals, which later became the only clinical institution training pediatricians. Over time, new archival facts become available, key events are being reinterpreted, and…
Objective. To study the effect of mineral water of Klyuchi Resort therapeutic and table mineral water on the intestinal microbiome of white mice with experimental dysbiosis. We have previously demonstrated the bacteriotropic effect of this mineral water on the obligate intestinal microbiota in vitro . The present study investigated the effect of this mineral water on the correction of experimental…
Objective. To study the impact of regular physical exercise on the dynamics of systemic metabolic inflammation biomarkers, body composition indices, muscle mass, and vascular elasticity parameters in patients with arterial hypertension who recovered from COVID-19. Materials and methods. This single-center prospective interventional study included 74 patients with hypertension 3 months after…
Objective. To conduct a comprehensive validation of the developed artificial intelligence model for bone age assessment using hand and wrist radiographs in children and adolescents. Materials and methods. Training a convolutional neural network for bone age regression (in months) using a dataset of hand and wrist radiographs from children and adolescents. Results. The mean absolute error (MAE) of…
Objective. Тo evaluate the feasibility, convenience, and effectiveness of diagnosing lung pathologies, including pneumonia, in children using a portable ultrasound system. The use of ultrasound in medical practice has become a landmark breakthrough, significantly improving the quality of care and increasing diagnostic accuracy. In terms of versatility and mobility, portable ultrasound systems with…
Objective. To identify the key features of children's functioning in the early intervention system, taking into account their existing clinical syndromes, activity limitations, and environmental factors. Materials and methods. The clinical diagnoses and primary neurological syndromes in children receiving early intervention services in 2019 are described. In assessing the level of functioning, the…
Objective. To determine early markers of developmental motor dysphasia. Neurodevelopmental disorders have various clinical manifestations, age of manifestation, and severity. One of the urgent tasks is to identify early predictors of deviant variants of children's development. Speech development disorder is observed in 3–7 % of observations in the pediatric population. Fundamental and early stages…
Objective. The present study expands our understanding of the role of sex and gender in the quality of life of patients with multiple sclerosis. Taking stress into account, allows a deeper investigation of the problem concerning the influence of sex and gender characteristics on the quality of life of patients with multiple sclerosis. Materials and methods. The study included 100 patients with…
Objective. To study the prevalence of sarcopenic obesity in adolescents, to substantiate diagnostic criteria, and to identify possible predisposing factors and consequences. Materials and methods . A standard clinical and laboratory study was conducted in 63 adolescents aged 12–17 years with obesity, including assessment of body composition, biochemical blood testing and hormonal profile analysis…