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Andre-Louis Moreau, known as Scaramouche, is the lawyer and actor at the center of Rafael Sabatini's French Revolution adventures.

Sonchai Jitpleecheep is John Burdett's Buddhist Royal Thai Police detective. The Bangkok crime series begins with Bangkok 8 and follows his homicide cases.

Sister Fidelma is the legal advocate and religious figure at the center of Peter Tremayne's seventh-century Irish mysteries. Her cases use the Brehon law system.

Scarlett Bernard is a Los Angeles null whose presence blocks supernatural power in Melissa F. Olson's urban fantasy series.

Simon Snow is the young magician at the center of Rainbow Rowell's fantasy trilogy. At Watford School of Magicks, he faces the Humdrum while his rivalry with his roommate Baz changes.

Sydney Fitzpatrick is the FBI forensic artist in Sydney Flitzpatrick's six-book thriller series, beginning with an investigation into her father's murder.

Sal Delaney is the lead of David Mark's northern English crime series, which begins with When the Bough Breaks.

Sam Chitto is a Choctaw Nation police officer who investigates unresolved crimes in Lu Clifton's southeastern Oklahoma mystery series.

Skink, whose real name is Clinton Tyree, is Carl Hiaasen's former Florida governor turned wilderness-dwelling vigilante. He first appears in Double Whammy.

Sutton McPhee is Brenda English's television reporter, whose three mysteries follow the stories she pursues about institutional corruption.

Stewart "Hoagy" Hoag is David Handler's novelist-turned-ghostwriter, whose celebrity assignments lead to murder cases with his basset hound Lulu nearby.

Dr. Samantha Willerby is a London psychotherapist whose cases lead into the psychological crime mysteries by A.J. Waines.

Stella Kendrick is the Kentucky heiress at the center of Clara McKenna's Stella and Lyndy Mystery series, where a move to Edwardian England leads to marriage and murder cases.

Sophie Foster is the telepathic girl at the center of Shannon Messenger's Keeper of the Lost Cities. When she learns she is an elf, she enters a hidden world and a growing conspiracy.

Sam Wiseman is a Montreal bookseller who becomes involved in the murder cases in Richard King's Book Shop Mysteries.

Sam Applewhite is a security consultant who handles offbeat mysteries on England's east coast in novels by Heide Goody and Iain Grant.

Sister June is the nun at the center of Amy Cross's six-book horror series. Her supernatural cases begin in The First Order.

Sam Graves is the student hall monitor who discovers his school is alive in Max Brallier's Eerie Elementary chapter-book series.

Sita, also known as Alisa, is the ancient vampire at the center of Christopher Pike's Last Vampire novels. Her story combines present-day danger with memories of her past in India.

Samantha Sanderson is a middle-school reporter who investigates school and community mysteries in Robin Caroll's series.

Scott Elliott is a former actor and veteran who handles security cases in postwar Hollywood in Terence Faherty's mysteries.

Savannah Martin is a Nashville real estate agent whose listings lead to murder cases in Jenna Bennett's mystery series.

Simon Templar, known as the Saint, is Leslie Charteris's gentleman adventurer and outlaw. The long-running crime series begins with Meet the Tiger.

Detective Steve Carella is the best-known member of Ed McBain's 87th Precinct squad, investigating crimes in the fictional city of Isola.

Skye Thorn is the protagonist of Jocelyn Davies's A Beautiful Dark trilogy. After her seventeenth birthday, she learns that she is tied to a conflict between the Guardians and the Shadows.

Sam Porter leads the 4MK task force in J.D. Barker's Chicago-set serial-killer thriller trilogy.

Stephanie Plum is Janet Evanovich's Trenton bail-enforcement agent, a former lingerie buyer who pursues fugitives while relying on friends, family, and a good deal of luck.

Sookie Stackhouse is the telepathic Louisiana waitress at the center of Charlaine Harris's Southern Vampire Mysteries. Her story begins in Dead Until Dark.

Summer is one of the Silverwood teenagers in The 'Naturals Season 1, a supernatural serial about students who begin to develop unusual abilities.

Savine dan Glokta is an investor and socialite in Joe Abercrombie's Age of Madness trilogy, set in the First Law world.

Sam Vimes is the commander of Ankh-Morpork's City Watch in Terry Pratchett's Discworld novels.