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Lexi Ventures Newsletters · Feb 17, 2026

February 2026

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Lexi Ventures Newsletters · Lexi Ventures Newsletters

Lexi Ventures is a VC firm with a unique focus on gene tech at seed stage.

I run Lexi Ventures as a solo fund manager with one amazing Venture Fellow. Thanks to AI, we operate like a mid-sized firm. Here’s how:

  • Screen decks: Instantly spot out-of-scope companies.

  • Deep dives: Pull public info, past emails, and docs to research people and companies.

  • Learn fast: Generate unbiased audio reports on science and industry. A quick Q&A gives me a near-expert-level understanding in hours.

  • Check docs: Instantly scan PDFs and screenshots to catch mistakes.

  • Create: I coded our new website on my phone in 30 minutes.

AI lets me do multiple person-days of work each day. More importantly, AI gives me better judgment for investment decisions.

The FDA just made it much easier to build cell and gene therapies. They relaxed rigid manufacturing rules, saving companies time and money while bringing cures to patients sooner.

But then, the FDA refused to review Moderna’s new mRNA flu vaccine. The previous FDA leadership approved Moderna’s trial design. The new leadership rejected the application, claiming the test used the wrong comparison. They changed the rules after an expensive, successful trial ended.

Takeaway: Good news for gene therapy investors, bad news for mRNA vaccine makers. FDA rules currently seem to depend heavily on one person’s opinions.

Dog breeds vary wildly in size, shape, and behavior compared to cats. Why? Dogs evolved to be social, making them trainable for different jobs, so we bred more varieties. Cats got one job: kill the fast-breeding rodents trying to eat our grain.

But there are also three genetic reasons it’s easier to breed dogs than cats:

  1. Mutation Rate: Dog DNA has repeating sections that mutate easily. Cat DNA is strictly ordered and rarely changes.

  2. Gene Structure: In dogs, one mutated gene can change their whole body. In cats, body shape changes require multiple genes mutating at once.

  3. Health Limits: When cat DNA mutates, it often causes severe health problems. Dogs easily survive extreme physical mutations and keep reproducing.

Thank you for your interest and support.

jonah@lexi.vc

Read the original on lexiventures.substack.com

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