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The Variant

Interesting twists in science and society. Kuan's essays on science in society, AI in medicine, and how to responsibly innovate at the edge of what's possible.

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The Most Misleading Sentence in Scientific Publishing

Why “available upon request” is not enough for scientific publishing, and how we might measure the science that shared datasets enable.

From 4 hours to 90 seconds: how I rewrote the software that reads DNA

Why I am rewriting the genomics software stack, and why now is the moment to do it.

Science Is Moving Too Fast for the Way We Review Papers

Why I launched JRNLClub, a better way to discuss papers

Why I Built LuciVida.com — A Personalized Health Platform for everyone

A foray into what supplements actually work in preventing deadly diseases — and toward a personalized AI health assistant for everyone

America, We’ve Got a Problem... ...

Defunding Science & Higher Education Is How We Lose the Future

Mendelity: Transparent Journal Choices by Impact & Price

Academic publishing at a time of funding uncertainty

The Inner Games People Play in Science

“In life, the challenge is not so much to figure out how best to play the game;