The 2DD podcast is about setting sights beyond the challenges in your life and dreaming big, making a plan, and then executing like mad. You are guaranteed an emotional rollercoaster, and practical thoughts that you can apply to your life with this podcast. Hosts Sean and Kyle are both affected by a rare disease called Friedreich’s ataxia (FA). FA affects their balance and coordination, significantly limiting their physical abilities. However both dudes have completed several long distance bike…
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In this special 300th episode of the Two Disabled Dudes Podcast, Sean and Kyle reflect on nearly 10 years of podcasting, the challenges of creating 300 episodes, and the incredible community that has formed along the way. From forgotten recordings and technical disasters to meaningful live events and lifelong friendships, they share stories from behind the scenes and revisit some of their favorite…
Sean and Kyle kick off this episode with a conversation about smart technology, AI, and the growing tension between convenience and commercialization in everyday life. That discussion sets the stage for a powerful interview with Joshua Resnikoff , founder and CEO of Sunstone Health , whose family’s rare disease journey inspired him to tackle one of healthcare’s biggest challenges: the long and…
Part 2 continues Debbie Drell’s story, focusing on the real-life impact of caregiving, invisible illness, and the need for empathy. Debbie highlights how much people take for granted—walking short distances, being in crowds, traveling, or getting through a full day without rest. For her sister Alex, who lives with multiple rare conditions including pulmonary hypertension, these everyday activities…
In this first part of the conversation, Sean and Kyle sit down with longtime friend and rare disease advocate Debbie Drell, whose connection to the space runs deep—both professionally and personally. Debbie shares the story of her sister Alex, who was diagnosed with pulmonary hypertension decades ago and given just two years to live—yet is still fighting today. As both a caregiver and advocate,…
Episode 296 explores connection, resilience, and the power of meeting people where they are—starting with a story about a young man with Friedreich’s ataxia (FA) who courageously continues cycling even after a crash. The episode’s main conversation features Dr. Eric Mitchell and his son Dylan, who share their work with Neurodiversity Consultants and their strengths-based, relationship-driven…
Another frustrating hotel experience opens the episode, but the real conversation centers on what it actually means to “never give up.” After dealing with a series of accessibility failures—miscommunication, poor accommodations, and a lack of understanding—Kyle and Sean shift into a bigger idea: persistence isn’t just about pushing harder. Using the story of a breakthrough Friedreich’s ataxia (FA)…
This episode starts with a classic 2DD moment—a wild but relatable story about Kyle discovering he had a piece of road stuck in his knee for a year and a half. It’s funny, a little absurd, and quickly turns into something more meaningful: how often we ignore small issues—physical or otherwise—and just learn to live with them instead of addressing them. From there, the conversation shifts into a…
In this special Rare Disease Day conversation, The Dudes partner with Jett Foundation to moderate a thoughtful panel on advocating for care needs, independence, and life with disability. Joined by Jake, Ashley, Charlie, and Xavier, the discussion highlights the many forms advocacy can take—from managing care and navigating insurance to simply showing up in the world, pursuing work, and building a…
What starts with airport chaos and accessibility frustrations turns into a meaningful conversation about what it really takes to move rare disease research forward. Sean and Kyle kick things off with travel stories from their trip to Rare At Sea , including misplaced mobility equipment, inaccessible hotel setups, and the all-too-common surprises that come with traveling disabled. Then they’re…
In this episode, Sean shares the bold details behind his upcoming climb of the Niesen Stairway in Switzerland—the world’s longest staircase with 11,674 steps, the equivalent of climbing the steps of the world’s tallest building nearly four times. Because the stairs are a private emergency access route alongside a mountain tram, Sean and his team will attempt the ascent overnight in the dark,…
