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Shawn's thoughts & musings

My explorations navigating emerging tech industries (AI, biotech) and venture models

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Superintelligent Corporations and how Claude Code Changes the AI Transformation Game

AI coding agents with long horizons start to eat enterprise SaaS and workflows

Agentic thoughts

On AI agents, research, and how the world has changed since my last post

Why we haven't made breakthrough medical progress in the internet era, part 3: our understanding of disease

We still can't beat chronic disease killers, and aging overall...yet

Why we haven't made breakthrough medical progress in the internet era, part 2: clinical trials

Success rates are falling, but some pharmacos outperform and the disruptors are coming

Why we haven't made breakthrough medical progress in the internet era, part 1: venture financing

They promised us cures for Alzheimer's, instead we got 145 cancer drugs

The TechBio Idea Maze: to be, or not to be, an AI-native Biotech?

Finding a path to TechBio success through the fog

TechBio at a Crossroads: Will It Learn from Digital Health’s Mistakes?

Software is not eating the life sciences and healthcare worlds…yet

Building 2046, Issue #2

Exploring identity in Web3, the opportunities for biotech, and a short quest to buy a NFT and change your identity

Building 2046, Issue #1

Building the world of 2046, today. It all starts and ends with DAOs.

Venture Studio Models, continued: the history and formula for repeatable value creation

Can anyone recreate the productivity of Bell Labs, much less in healthcare?