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Sam Rodriques

Sam Rodriques

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The Humanity Project

Disclaimer: I run Edison Scientific, a company building an AI Scientist to automate scientific research and development. Our AI Scientist supports partners in biotech and pharma across the entire pipeline of drug development, including hypothesis generation, target identification, and target validation as discussed here, among other things. GLP-1 agonists are revolutionizing humanity’s approach to…

The end of benchmarks

Imagine a society of apes trying to play tic tac toe. One day, they meet a very good human player, who also has a computer that has a superintelligent AI on it, trained to play tic tac toe. From their perspective, both the human and the computer perform equally well; they can stalemate each other every time, and they often beat the apes. Even if the superintelligent AI is much better than the…

Thoughts on Uploading

I have a background in neuroscience and currently work on AI, so people often ask me for my thoughts on uploading. I thought I would...

The Grugbrained CEO

These words inspired by grugbrain.dev . If feel confuse, read grugbrain.dev first. Give good idea on how make good code and be less...

Rocket Ships and Yachts

Recently, we were courting an extraordinary candidate, who was deciding between joining FutureHouse or taking a job at one of the...

Europe

Monday was my last day as a group leader at the Francis Crick Institute. I got my job at the Crick in 2020, almost exactly 5 years ago,...

All-hypothesis research

First we had hypothesis-driven research. But our measurement techniques have become so high-throughput that investigating one hypothesis...

The essential role of natural language in representing biology

At the time of writing, it is December 2024, and I am at NeurIPS. The word of the day, at least in the AI for Biology community, is...

What does it take to build an AI Scientist?

What will it take to build an AI Scientist? I run FutureHouse, a non-profit AI-for-Science lab where we are automating research in...

If it is true that consciousness is realistic, then quantum computers cannot be conscious

If you want to read what I have written about consciousness previously, see https://www.sam-rodriques.com/post/can-we-build-a-consciousne...

Some considerations on brain-computer interfaces

I was speaking recently to a friend who is interested in starting a brain-computer interfacing company about the challenges and...

Protocols are long (and full of horrors)

I think the reason automating science is hard is that protocols often have 20+ steps; but each individual step will fail or require...

Key problems to accelerate medicine

Progress in medicine is slow. Exact numbers depend on subfield and source, but it takes ~5-10 years to test a new drug, ~93% of drugs...

Who follows Richard Ngo on Twitter?

Richard Ngo recently posted the following poll on Twitter. I bet him that the mode of the poll would be the 7+ option. I lost this bet,...

Things we learned starting FutureHouse #1: You can hire people who know more than you do*.

We launched FutureHouse in September. Prior to that, I was an academic. In academia, you are a teacher, and so you are always hiring...

New ideas

When people ask me what FutureHouse is doing, I tell them, FutureHouse is automating discovery. Scaling up biology research. Building AGI...

Focus areas for accelerating early-stage biology research with AI

Acknowledgments to Cameron Roots, Adam Marblestone, Tony Kulesa, and Logan Graham. Background: Machine learning has extraordinary...

Some tips on starting a FRO

Lots of people have approached me recently to ask for advice about how to start a Focused Research Organization. Here are the most...

Questions to ask about building foundation models

I often hear proposals to build new foundation models for biology. Here is the list of questions I ask. I rarely get past question 1....

Optical Microscopy Provides a Path to a $10M Mouse Brain Connectome (if it eliminates proofreading)

In a recent article [1], the Wellcome Trust estimated that it would cost roughly $10B over 17 years to reconstruct a whole mouse brain,...