Tiny Perfusion Letter #824

They say life can be a rollercoaster

And every now and then, it feels like you’re stuck going downhill, when all the fun happens and you’re moving rapidly, turning sharply and go a little uphill, to move down again fast… Whoopie

While you’re in that situation, you sometimes go so fast that you can’t see what is happening next to you, or you don’t have the time to do what you usually do

We guess that’s why it is that we haven’t gotten to a TPL lately, which gives YOU, the reader, a break, but also means that WE at TPL would like to catch up…

Anyway, a lot of words to tell you that we’re having a loaded edition, once again

#enjoyandshare

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Preoperative IV Iron and Postoperative Blood Transfusion Reduction in Non-anaemic Patients Undergoing Cardiac Surgery: A Systematic Review and Meta-analysis of RCTs.

Murad ZA, Lahcen AA, Alkhawam M, Elbasosy MY, Abdelhamid MO et al.

J Cardiothorac Surg. 2026 Jun 6. Online ahead of print OPEN ACCESS

Association between Intrarenal Venous Flow and Postoperative Acute Kidney Injury in Cardiac Surgery Patients following Cardiopulmonary Bypass: A Prospective Cohort Study.

Zhao J, Li Z, Wang W, Fu S, Fu Q, Fu S.

BMC Cardiovasc Disord. 2026 Jun 2. Online ahead of print OPEN ACCESS

Role of Sex Hormones in Early Neurocognitive Decline After Cardiac Surgery: An Exploratory Analysis.

Zheng CR, Stanley ME, Sawka DM, Ehsan A, Sodha NR, Sellke FW.

Ann Thorac Surg Short Reports. 2026 May 17. Online ahead of print OPEN ACCESS

Considerations to Practice a Safe and Minimal Administration of Heparin and Protamine during Cardiopulmonary Bypass.

Lee MH, Shann KG, Rosenthal T.

J Extra Corpor Technol. 2026 Jun;58(2):164-171 OPEN ACCESS

Quantitative Cerebral Perfusion Monitoring Using Transit-Time Flow Measurement During Neonatal Aortic Arch Surgery: A Case Report.

Orioli V, Careddu L, Agulli M, Sperandeo F, Berardi M, Mangerini VF, Angeli E.

ASAIO J. 2026 Jun 9. Online ahead of print OPEN ACCESS

Antidotes for Anticoagulation Reversal.

Rocca B, Ten Cate H.

N Engl J Med. 2026 Jun 11;394(22):2235-2254

Evidence-based Clinical Applications of Minimal Invasive Extracorporeal Circulation: From Pathophysiological Protection to a Precision Perfusion Platform.

Xiong H, Chang L, Yang Y, Chen T, Jin Z, Chen D.

ECLS. 2026;1(1):48-57 OPEN ACCESS

Beating Heart Implantation: A Comprehensive Technical Perspective

Elde S, Krishnan A, Liou KS, Fawad M, McNulty J et al.

Oper Tech Thor Cardiovasc Surg. 2026;31(2):80-90 OPEN ACCESS

Accelerated Epigenetic Ageing in Congenital Heart Disease: The AccelerAGE Study.

Tournoy TK, Daelman B, Demulier L, Brooke RT, Van De Bruaene A et al.

Eur Heart J. 2026 Jun 11. Online ahead of print

Time of Day of Cardiac Surgery and Postoperative Outcomes In the UK: A Secondary Analysis of Linked National Datasets.

Kitchen G, Thomas K, Felton T, Durrington H, Blaikley J et al.

Anaesthesia. 2026 Jun;81(6):775-782 OPEN ACCESS

Ethical Leadership in Cardiothoracic Surgery in an Era of Consolidation: A Framework for Trust, Transparency, and Workforce Stability.

Shuhaiber J.

J Thorac Cardiovasc Surg. 2026 May;171(5):1169-1176 OPEN ACCESS

Hemodynamic Principles of Arterial Cannulation: Orientation, Wall Shear Stress, Turbulence, Plaque Destabilization, and Cerebral Microembolization.

Condello I, Dell’Aquila M, El Dsouki Y, Condello S, Falco G et al.

Asian Cardiovasc Thorac Ann. 2026 Jul;34(6):551-559

Side-Clamping Versus Single Cross-Clamping in On-Pump CABG: Impact on Early Hematologic Outcomes and Blood Conservation.

Öntaş H, Gözüaçık Rüzgar AA.

J Clin Med. 2026 May 27;15(11):4124 OPEN ACCESS

Advances in Cardiovascular Pharmacotherapy. VIII. Angiotensin II in Vasodilatory Shock.

Pagel PS, Hang D, Freed JK, Crystal GJ.

J Cardiothorac Vasc Anesth. 2026 Apr 1. Online ahead of print

Evaluation of Nosocomial Infections after Congenital Heart Surgery in Children: a Comprehensive Analysis Including the Systemic Immune-inflammation Index.

Tak S, Demirdağ TB, İriz E, Yiğiter EN, Shide IAA et al.

Front Pediatr. 2026 May 26;14:1735292 OPEN ACCESS

Perioperative Immune Dynamics during Cardiopulmonary Bypass and Association with Major Adverse Postoperative Events.

Cheng Z, Liao X, Wu J, Yang P, Wu Q et al.

Front Cardiovasc Med. 2026 May 26;13:1811178 OPEN ACCESS

Perioperative Normoxia Versus Hyperoxia in Cyanotic Congenital Heart Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Gonçalves LB, Delgado LM, Oliveira RENDN, Carvalho EÁ, Loftin M, Tenório DF.

World J Pediatr Congenit Heart Surg. 2026 Jun 11. Online ahead of print

Exploring Carboxyhemoglobin as a Predictive Marker of Hemolysis-related CSA-AKI.

Terrenghi S, Duceau B, Dureau P, Campeanu A, Djavidi N et al.

J Clin Anesth. 2026 Jun 10;113:112260. Online ahead of print OPEN ACCESS

Cognitive Dysfunction after Cardiac Surgery: A Systematic Review and Meta-analysis On the Mini-mental State Examination Findings.

Cheng H, Yasen Y, Cheng X, Hu Z, Li X et al.

Biomed Rep. 2026 May 26;25(1):89 OPEN ACCESS

Effect of Different Priming Fluids on Extravascular Lung Water, Cell Integrity and Oxidative Stress in Cardiopulmonary Bypass Surgery.

Ulugöl H, Can MG, Aksu U, Vardar K, Ökten M, Toraman F.

Cardiovasc J Afr. 2024 May-Aug 1;35(2):70-74

Multi-Output Machine Learning for Prediction of Postoperative Outcomes After Cardiac Surgery Using Patient Blood Management Biomarkers.

Coelho H, Paupério D, Silva F, Barbosa MI, Ribeiro P et al.

J Clin Med. 2026 May 29;15(11):4221 OPEN ACCESS

Survivors of Cyanotic Congenital Heart Disease: A Review.

Egidy Assenza G, O’Leary E, Brida M, Kwon M, Landzberg MJ.

JAMA. 2026 Jul 7;336(1):56-68 OPEN ACCESS

Management Algorithm for Vasoplegic Shock after Cardiac Surgery: An Interdisciplinary Collaboration.

Chatterjee S, Ortoleva J, Arora RC, Dalton KR, Engelman DT et al.

Ann Thorac Surg. 2026 Jun 17. Online ahead of print OPEN ACCESS

Fibrinogen/Albumin Ratio and Outcome in Adult Cardiac Surgery With Cardiopulmonary Bypass.

Casalino S, Anguissola M, Barbaria A, Aloisio T, Baryshnikova E, Landi G, Ranucci M.

Anesth Analg. 2025 Nov 25. Online ahead of print

Comparison between Three Single-dose Cardioplegic Solutions in Myocardial Protection: Cardioplegia Trial - A Double-blind Randomised Clinical Trial.

Lira KB, Delvaux RS, Spadini FA, Anschau F, Kopittke L et al.

Heart. 2026 May 28. Online ahead of print OPEN ACCESS

Perioperative Metabolomic Profiling in Neonatal Cardiac Surgery Identifies a High-Risk Phenotype for Adverse Outcomes.

Cooney SJ, Chinni BK, Graham EM, Russell M, McCrindle BW et al.

JACC Adv. 2026 May;5(5):102745 OPEN ACCESS

Cardiopulmonary Bypass Effects on Minimum Alveolar Concentration and Other Bypass Terminology.

Grocott HP.

Anesth Analg. 2026 May 27. Online ahead of print OPEN ACCESS

Plasma from Cardiac Surgery Patients Induces Endothelial and Tubular Epithelial Cell Damage: Potential Role in Acute Kidney Injury Development-A Preliminary Report.

Grossini E, Esposito T, Venkatesan S, Ola Pour MM, Cantaluppi V et al.

Int J Mol Sci. 2026 May 15;27(10):4416 OPEN ACCESS

The Gut Microbiome in Congenital Heart Disease: Dysbiosis, Intestinal Barrier Injury, and Translational Opportunities Across the Childhood-A Narrative Review.

Luca AC, Mindru DE, Rosu ST, Diaconescu C, Rosu EV, Țarcă E, Adumitrăchioaiei H, Anton-Paduraru DT.

Children (Basel). 2026 May 11;13(5):668 OPEN ACCESS

The Role of Glucagon-Like Peptide-1 Receptor Agonists in Mediating Myocardial Resilience in Cardiac Surgery.

Venkatesan A, Martin A, Katragadda N, Tsui S, Otten M et al.

Cardiol Rev. 2026 May 25. Online ahead of print

Protamine Dosing in Cardiac Surgery: Method is Key.

Beukers AM, Mansvelder FJ, Eberl S, Hermanns H.

J Thorac Dis. 2026 Apr 30;18(4):450 OPEN ACCESS

Push the Flow - Mind the Micro: Renal Microcirculation during High-flow Cardiopulmonary Bypass.

Langouet E, Ouattara A, Tafer N, Villemain O.

J Thorac Dis. 2026 Apr 30;18(4):446 OPEN ACCESS

Cardiopulmonary Bypass Complications and Their Predictors in Open-heart Surgery at a Tertiary Cardiac Care Facility in Tanzania.

Luvakule AD, Gamba SF, Lugazia ER, Loth A.

Glob Cardiol Sci Pract. 2026 Apr 30;2026(2):e202611 OPEN ACCESS

Challenges of Intra-Aortic Balloon Pump and Extracorporeal Membrane Oxygenation in Cardiogenic Shock: Real-World Outcomes.

Wang WT, Lee CY, Huang SS, Fung E, Huang PH et al.

Acta Cardiol Sin. 2026 May;42(3):413-428 OPEN ACCESS

Con: Viscoelastic Testing Should Not Be Used Routinely but Selectively in Cardiac Surgery.

Cameron M, Awad T.

J Cardiothorac Vasc Anesth. 2026 Apr 27. Online ahead of print

Pro: Point-of-care Viscoelastic Testing Should Be Routinely Used in All Cardiac Surgery Patients.

Galhardo C Jr,, Sheriffdeen R.

J Cardiothorac Vasc Anesth. 2026 May 22. Online ahead of print

Fatigue Risk Management in Healthcare: A Scoping Literature Review.

Fox S, Dall’Ora C, Young M.

Int J Nurs Stud. 2026 Feb;174:105282 OPEN ACCESS

Heparin Activity Following Titration-Guided Protamine Reversal After Cardiopulmonary Bypass: Impact on Postoperative Bleeding,

Tornudd M, Ramstrom S, Escobar Kvitting JP, Alfredsson J, Lindahl TL, Berg S.

J Cardiothorac Vasc Anesth. 2026 Jun 30. Online ahead of print OPEN ACCESS

Mortality and Risk Factors in Pediatric Cardiac Surgery for Congenital Heart Disease in Mexico.

Leyva-López Y, Cerano-Fuentes JL, Calderón-Colmenero J, Cervantes-Salazar JL.

World J Pediatr Congenit Heart Surg. 2026 Jun 2. Online ahead of print

Antithrombin and 20% Albumin as Treatment of Oxygenator High Pressures Excursion during Cardiopulmonary Bypass in Cardiac Surgery: A Case Report.

Mandarano R, Pedevilla S, Annese F, Pessetti L, Squiccimarro E et al.

Int J Artif Organs. 2026 Jul;49(7):468-472

Development of a Hemolysis Filter System for the Selective Removal of Free Hemoglobin, Haem and Iron from Blood Envisaged for Use in Extracorporeal Circuits.

Naghavi N, Barbaro L, Griffiths MJ, Davidson S, Melley DD et al.

Sci Rep. 2026 Jul 1. Online ahead of print OPEN ACCESS

TM and t-PAIC May be Possible Biomarkers to Predict Postoperative Infection after Cardiac Surgery with Cardiopulmonary Bypass.

Wang L, Chen Q, Wu W, Long Y.

J Cardiothorac Surg. 2026 Jun 14. Online ahead of print OPEN ACCESS

Association of Surgeon Sex with Postoperative Adverse Outcomes in Adult Cardiac Surgery: A Nationwide Cohort Study.

Arnreiter M, Kaider A, Pljakova M, Angleitner P, Osipenko K et al.

J Cardiothorac Surg. 2026 Jun 13. Online ahead of print OPEN ACCESS

Patient and Family-centered Concerns in Pediatric Cardiac Surgery: a Middle Eastern Perspective.

Jha NK, Hassan AA, Elmahi M.

J Cardiothorac Surg. 2026 Jun 12. Online ahead of print OPEN ACCESS

Timing Matters: Association of Persistent Postoperative Anemia with Adverse Outcomes in Cardiac Surgery.

Zhang X, Nie Y, Zhang R, Zhang Q, Wang X.

J Cardiothorac Surg. 2026 Jun 12. Online ahead of print OPEN ACCESS

How To Dose Prothrombin Complex Concentrates in Bleeding Patients After Cardiac Surgery.

Bolliger D, Mauermann E, Tanaka KA.

J Cardiothorac Vasc Anesth. 2026 Jul;40(7):1977-1979

Anticoagulation Monitoring Strategies During Cardiopulmonary Bypass in Patients With Antiphospholipid Syndrome: A Systematic Review.

Yoshida S, Ishida O, Tsutsumi K.

J Cardiothorac Vasc Anesth. 2026 Jul;40(7):2004-2014 OPEN ACCESS

Perioperative Hypoxaemia Early Warning Based on High-frequency Waveform Fusion and Deep Learning.

Wang C, Dong L, Yu M, Chen W, Liu B, Zhang G.

Physiol. Meas. 2026, 47(5):55017

Numerical Analyses of Blood Pumps Under Realistic Operating Conditions.

Klocker S, Grujic M, Schöfbeck R, Thamsen B, Torner B et al.

ASAIO J. 2026 Jun 1;72(6):477-485 OPEN ACCESS

Association between Circulating Biomarkers of Endothelial Glycocalyx Degradation and Postoperative Acute Kidney Injury in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass.

Wang M, He M, Hong L, Shen Y, Wang, Sun Y.

Front. Surg. 2026 Jul 12;13:1863142 OPEN ACCESS