Trained immunity of M1-like foamy macrophages: A key role of human endogenous retrovirus K102 particles.

Dr. Marian Laderoute, Ph.D. Immunology (A.R.T.)@hervk102

Pinnacle Paper on Potent Protection against disease Progression PUBLISHED! I am pleased to announce after many months and a lifetime of hard work (and more recently struggling horribly with dyslexia) my review paper has been published on how trained immunity launches potent

5:22 PM · Jun 27, 2026 · 948 Views

1 Reply · 2 Reposts · 3 Likes

I think we have to step back and realize that adaptive immunity vaccination against viruses has a faulty foundation generally speaking and as recently voiced by Dr. Peter McCullough on Friday June 26 2026.

Peter A. McCullough, MD, MPH®@P_McCulloughMD

The Herd Immunity Myth Behind Childhood Vaccine Mandates Vaccinology doctrine assumed sterilizing, lifelong protection. Most routine vaccines offer neither. Continuing to mandate based on that fiction is a policy catastrophe with profound consequences. @johnsearsleake

10:16 AM · Jun 26, 2026 · 22.3K Views

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The good news is that also on Friday June 26, 2026, an article was published revealing how trained (INNATE) immunity generated in macrophages can instead mediate sterilizing and herd immunity and is available here free for downloading:

https://www.accscience.com/journal/GTM/articles/online_first/8098

Please like and share this post widely to get the word out.

Marian P. Laderoute. Trained immunity of M1-like foamy macrophages: A key role of human endogenous retrovirus K102 particles. Global Translational Medicine 025370071. https://doi.org/10.36922/GTM025370071

https://www.accscience.com/journal/GTM/articles/online_first/8098

I think that the delay in understanding trained immunity and its potent protection against pandemic viruses and cancer is because the cell that generates the protection undergoes lysis to launch the protection; therefore it would be hard to follow the action of ‘disappearing innate immunity cells: the M1-like foamy macrophages’.

Some comprehensive investigations however did identify the M1-like foamy macrophages in protection against SARS-CoV-2 and that only these cells and their precursors (the intermediate monocytes in blood) exclusively had highly activated vitamin D regulons detectable (only 2 /64 cell types in bronchoalveolar lavage fluids (BALF)).

Ren X, Wen W, Fan X, et al. COVID-19 immune features

revealed by a large-scale single-cell transcriptome atlas. Cell.

2021;184(7):1895-1913.e19.

doi: 10.1016/j.cell.2021.01.053

Given the clinical significance of the launch of the HERV-K102 PARTICLE protector system in M1-like foamy macrophages (Image 1): and that adequate vitamin D blood levels support and prioritize M1-like foamy macrophages and prevent the M1 to M2 transition of foamy macrophages (Image 2): in this way, how vitamin D becomes a major determinant of health (promotes wellness) and can result in reduction in morbidity and mortality in populations are easily explained and understood.

Please share this post widely. I thank you in advance.

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