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David Gillespie's Fortnightly Briefing · Jul 22, 2026

The Thermodynamics of Smugness

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David Gillespie · David Gillespie's Fortnightly Briefing

There is a spectacular arrogance in believing you can outsmart millions of years of human evolution with a pocket calculator and a gym membership. For a century, the medical establishment has peddled the most aggressively dull, dangerously flawed maths equation in human history. They tell us that human beings are simple furnaces and that all calories are created equal. It is a comforting fairy tale for the metabolically blessed. It allows society to completely ignore the fact that the modern supermarket is essentially a drug cartel, aggressively pushing a bespoke poison called fructose that guarantees we never stop eating.

If there is one thing modern society loves more than a quick fix, it is a prolonged, agonizing martyrdom. We have replaced the sackcloth and ashes of the Middle Ages with the modern gym and the calorie counting app.

Go back to the late 19th and early 20th centuries, before the clipboard wielding sadists of the diet industry took over, and you will find a group of European clinicians who held a view of obesity that would cause a modern personal trainer to spontaneously combust. They believed the biological drive to fatten caused a person to overeat, not the other way around. Some even went so far as to prescribe complete, unadulterated bed rest for their obese patients.

While this sounds like sheer madness to a generation conditioned to repent for their sins on a Peloton, their reasoning was rather profound. They recognized that rapidly expanding fat tissue was essentially acting like a ravenous parasite, hoarding the body’s energy and leaving the rest of the organs quite literally starving. The profound lethargy of obesity wasn’t a failure of character. It was a desperate symptom of cellular energy depletion.

This historical footnote invites us to reconsider the deeply ingrained, aggressively dull paradigm of “Calories In/Calories Out” (CICO), a dogma so universally accepted it has become the flat earth theory of human biology.

For decades, CICO has been the cornerstone of dietary advice. The premise is seductively, dangerously simple. If you consume more energy than you expend, you expand. If you burn more than you swallow, you shrink. It reduces the magnificent, chaotic, deeply paranoid survival machine that is the human body to the level of a primary school maths equation. It tells us, incessantly, that obesity is simply a matter of weak willpower, conveniently ignoring the fact that the modern food supply has been systematically flooded with a biochemical saboteur designed to break our internal scales. That saboteur is fructose.

The Moral Seduction of a Flawed Equation

Why has such a spectacularly simplistic explanation survived a century of mounting, glaring scientific evidence to the contrary? Because the CICO model is not merely a biological theory. It is a theology. It is a grim, joyless little religion that offers a highly intoxicating psychological reward to those who do not happen to struggle with their weight. It grants the unearned glow of moral superiority.

If body weight is purely a matter of conscious energy management, then thinness is no longer just a state of being. It becomes a virtue. It transforms a flat stomach into a visible trophy of discipline, stoicism, and grace. Conversely, obesity is reduced to a moral failing, a physical manifestation of gluttony and sloth wrapped in a tracksuit.

This framing is deeply, darkly appealing. It allows the metabolically blessed to point a manicured finger at the perceived faults of others as a way to feel positively angelic about their own genetic luck. It replaces empathy and scientific curiosity with sanctimonious judgment, placing the entirety of the blame on individuals while entirely absolving the food industry that stealthily pumps cheap, addictive fructose into everything from bread to salad dressing. It is a way for the thin to look at the fat and say, “I am simply better than you,” blissfully ignoring the weaponized food environment we all inhabit.

The Thermodynamics Trap

When cornered, the defenders of this faith inevitably retreat to their citadel of physics. They rely on the First Law of Thermodynamics. Energy, they will lecture you with the weary patience of a saint dealing with a simpleton, can neither be created nor destroyed. Therefore, weight gain must be a surplus of calories. A calorie of broccoli, they insist, is identical to a calorie of Tim Tams.

While the laws of physics are indeed inviolable, the CICO interpretation of them is fundamentally, almost comically, flawed. The First Law dictates that energy balance must be maintained, but it says absolutely nothing about causality, nor does it account for hormonal alchemy. You are not a Victorian steam engine. If you artificially restrict your calories in, your body, which has survived millions of years of famine, ice ages, and plagues, will immediately and ruthlessly reduce your calories out to maintain homeostasis.

The Proof of Metabolic Adaptation

If you want proof of this, you need look no further than that grotesque, weeping carnival of human misery, The Biggest Loser.

The television show subjected its contestants to the ultimate CICO protocol of near starvation coupled with punishing, gladiatorial exercise. And they lost massive amounts of weight. But when researchers from the National Institutes of Health followed up years later, they found something that should have destroyed the CICO myth forever. The contestants’ metabolisms hadn’t just slowed down. They had packed their bags and gone on permanent strike.

Their bodies, terrified by the manufactured famine, aggressively adapted. The resting metabolic rate of the contestants plummeted by hundreds of calories a day. Even years later, their biology was actively fighting the CICO math, slowing their internal engines to a crawl in a desperate, evolutionary bid to regain the hoarded energy. You cannot simply manipulate “Calories In” without the body exacting its revenge by shutting down “Calories Out.”

The Parasite Within. The Fructose Con

If a calorie deficit isn’t the primary driver of weight loss, what is? The answer lies not in mathematics, but in hormones. To truly understand the sheer maliciousness of the modern food environment, we must look at the king of this grim carnival. That king is fructose. If a sociopathic biochemist set out to design a substance explicitly to sabotage human metabolism, bypass satiety, and pervert our natural ability to regulate energy, they could not improve upon it.

Unlike glucose, which is at least registered by the body’s satiety signals, fructose slips past the guards. Its calories are practically uncounted by the brain. It does not trigger fullness. Instead, it makes a beeline for the liver, where it triggers a catastrophic process called de novo lipogenesis, literally the making of new fat from scratch.

But the true malice of fructose lies in what happens next. As the liver gets choked with this freshly minted fat, it becomes increasingly deaf to the body’s insulin signals. This is a state of metabolic gridlock known as hepatic insulin resistance. The pancreas, observing that the liver is ignoring its instructions, panics. It pumps out more and more insulin, flooding the system in a desperate bid to be heard and bring blood sugar under control.

This chronic, roaring flood of insulin is the absolute ruin of the metabolic ledger. Insulin, you see, is the body’s tyrannical master fat storage hormone. When insulin levels are artificially and chronically elevated by this fructose induced panic, fat cells are given a single, unyielding command. Store energy, and firmly lock it away. The vault doors are welded shut.

The Reversed Causality. Why We Overeat

This is where the forgotten wisdom of those early 20th century clinicians becomes brilliantly clear, changing the entire paradigm. We do not get fat because we overeat. We overeat because our fat tissue is growing.

We accept this obvious causality in absolutely every other biological scenario. When a teenage boy suddenly devours everything in the pantry, we do not accuse him of gluttony. We certainly do not assume his ravenous appetite is magically stretching his bones and making him taller. We understand instinctively that the biological imperative to grow is driving his hunger. When a pregnant woman consumes extra meals, we do not scold her for lacking willpower. We know the immense physiological demand of laying down fat reserves and building a baby is commanding her appetite. Yet when it comes to obesity, society stubbornly reverses the arrow of causation.

When hyperinsulinemia forces calories into fat cells, those calories are trapped. They are no longer circulating in the bloodstream to fuel the brain or the muscles. The body registers this as a state of acute cellular starvation. And how does a starving creature react? It triggers a primal, overwhelming hunger, forcing you to consume more energy to satisfy a fructose addiction you cannot physically beat.

Simultaneously, it makes you feel deeply lethargic, anchoring you to the sofa to conserve whatever precious little fuel is left circulating. The overeating and the inactivity are not the causes of the growing fat tissue. They are the desperate, flailing symptoms of a body whose hormonal thermostat has been shattered by the food we consume.

Moving Beyond the Puritanical Abacus

The “Eat Less, Move More” mantra is not just a scientific failure. It is a profound cruelty. Decades of this puritanical advice have conveniently coincided with an unprecedented explosion in global obesity. By telling people to simply eat less when their hormonally broken fat cells, poisoned by a lifetime of cheap, ubiquitous fructose, are aggressively hoarding energy, we are effectively telling a starving person to cure themselves by starving a little bit more. It is biological sadism masquerading as medical advice.

Understanding obesity requires us to discard this puritanical abacus. We must strip away the moralizing, the judgment, and the smugness, and confront the biochemical reality of human metabolism. It is time our approach to weight loss stopped treating the human body like a moral scorecard, and started treating it with the scientific respect, and righteous fury at a corrupted food supply, it actually deserves.

Read the original on dgillespie.substack.com

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