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Askwho Casts AI · Aug 13, 2026

The Quest For Caffeine You Can Have At Night

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What if you could get the useful part of caffeine without still feeling it at bedtime?

What if you could get the useful part of caffeine without still feeling it at bedtime? Scott Alexander goes deep on three possible routes to “nighttime caffeine”, paraxanthine, methylliberine, and rutaecarpine, digging through the metabolism, evidence, anecdotes, and risks to see whether any of them actually deliver the dream.

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  • 00:00 - Introduction

  • 04:47 - The Enzyme

  • 16:03 - The Metabolite

  • 21:58 - The Starting Chemical

  • 26:55 - Practical Protocols

Astral Codex Ten
The Quest For Caffeine You Can Have At Night
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5 days ago · 158 likes · 72 comments · Scott Alexander

https://open.substack.com/pub/astralcodexten/p/the-quest-for-caffeine-you-can-have?r=67y1h&utm_campaign=post-expanded-share&utm_medium=web

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