2-Phenyl-1-benzothiophene
Appearance
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| Preferred IUPAC name
2-Phenyl-1-benzothiophene | |
Other names
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3D model (JSmol) |
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| Properties | |
| C14H10S | |
| Molar mass | 210.29 g·mol−1 |
| Melting point | 171.5 °C (340.7 °F; 444.6 K)[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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2-Phenyl-1-benzothiophene is an aromatic chemical compound commonly used as an intermediate in the production of medication. Derivatives of the compound are present in drugs used to treat Alzheimer's disease, and its structure is present in the selective estrogen receptor modulator drugs raloxifene and arzoxifene.[2] Its formula is C14H10S.
2-Phenyl-1-benzothiophene is an intermediate in pesticide synthesis, in addition to its uses in the pharmaceutical field. Typically, it is produced through three methods: an arylation reaction of benzothiophene; a coupling reaction between 2-benzothiophene boronic acid and a benzene-donating compound; or cyclization of aromatic molecules.[3]
References
[edit]- ↑ Williams, Antony John; Lowe, Daniel; Tetko, Igor (2015). Melting Point and Pyrolysis Point Data for Tens of Thousands of Chemicals. Figshare. doi:10.6084/M9.FIGSHARE.2007426.
- ↑ Zhong, Yu-Jie; Zhao, Ke-Qing; Wang, Bi-Qin; Hu, Ping; Monobe, Hirosato; Heinrich, Benoît; Donnio, Bertrand (2020). "2-Phenylbenzothiophene-based liquid crystalline semiconductors" (PDF). Dyes and Pigments. 173 107964. doi:10.1016/j.dyepig.2019.107964.
- ↑ Duan, Zhongyu; Gao, Yujuan (June 1, 2013). "Recent Progress in the Synthesis of 2-Phenyl-benzo[b]thiophene". Chinese Journal of Applied Chemistry. 30 (6): 611. doi:10.3724/SP.J.1095.2013.20394. ISSN 1000-0518.
