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Amy Hollenkamp, MS, RD · Jun 24, 2026

Histamine and IBS Connection

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Is histamine driving your IBS symptoms? What are the best ways to manage histamine levels?

This post is exclusive to paid subscribers. Each month paid subs get a special post. Next week, I will return with more free content!

Histamine has been a hot topic in the health space the last 5 or so years. I have worked clinically with patients that have struggled with histamine issues or MCAS. I see so many internet posts about histamine being a driver of many health conditions including IBS. Unfortunately, I have seen many patients who go deep into the histamine rabbit hole only to exit worse off than when they started.

I have see many taking low histamine diets to the EXTREME. Histamine is in virtually everything. Some of the low histamine diets make Low FODMAP look like a walk in the park.

In the gut health space, I see many patients blaming histamine intolerance on gut imbalances. While dysbiosis could lead to histamine issues, I rarely see this being the full story.

I’m hoping that in this article, we can discuss the research linking histamine issues and IBS. I also want to share clinical pearls I have seen working with patients who struggle with histamine intolerance. What seems to help these patients the most?

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