Continuous Light and Pinealectomy: Two Models of Melatonin Deficiency Revealing Distinct Interactions with Vitamin D Deficiency on Blood Parameters

Modern lifestyles reduce sunlight exposure and increase artificial light at night, potentially promoting vitamin D deficiency (VDD) and melatonin (MEL) suppression. The two hormones regulate immunity, erythropoiesis, and platelet (PLT) indices, but their combined hematological effects are not well characterized. We investigated the independent and combined effects of VDD and MEL deficiency on…