Five flavors of stratified LD score regression (Part 1, Vanilla)

Linkage disequilibrium score regression (LDSC) is a workhorse technique at the intersection of quantitative genetics and functional genomics. The core use of S-LDSC is to detect and quantify functional enrichment of genetic associations; for example, “Are STAT1 binding sites enriched for genetic risk of Crohn’s Disease?” or “Are CNS-specific enhancer regions enriched for effects on psychiatric…