Blog 26 – Estimands Part 3A – What Is the Question?

Even with the publication of ICVH E9(R1) and so may efforts globally for explaining and implementing the estimand framework, too often statisticians, and clinical researchers in general, focus their efforts on how to handle incomplete data, which is my term for the missing or confounded data created by so-called intercurrent events. Let’s get the focus on the clinical question of interest.