Delayed effect asymptotic approximations and simulation

Overview&#xD;Computing preliminaries&#xD;Design assumptions&#xD;Fixed design&#xD;Simulation of fixed design&#xD;Group sequential design&#xD;Same design with weighted logrank&#xD;Accumulation of events and average treatment effect over time&#xD;Alternate analysis timing and \(\alpha\)-spending strategies&#xD;Simulation to verify operating characteristics&#xD;Simulate a single trial and perform…