Minibwa is the new bwa-mem

Preprinted in 2013 , bwa-mem is a popular mapper for 100+ bp short reads. It is often the first choice in variant calling pipelines for human data. However, bwa-mem has increasingly become the performance and the cost bottleneck when the upstream/downstream get optimized. This led to multiple forks, including bwa-mem2 , bwa-meme , Sentieon bwa and Parabricks bwa , which produce identical or near…