ACC 2026 Highlights: New Frontiers in Myosin Inhibition

Drs. de Feria and Owens review emerging data on cardiac myosin inhibitors for obstructive hypertrophic cardiomyopathy, from adolescent therapy to interruption and reinitiation of treatment. They highlight impacts on left ventricular outflow tract gradients, symptoms, biomarkers, and practical periprocedural management.