Sivelestat may reduce the risk of acute respiratory distress syndrome in adults undergoing cardiac surgery

1. Sivelestat significantly reduced the incidence of postoperative acute respiratory distress syndrome (ARDS) compared to placebo in adult patients undergoing cardiac surgery requiring cardiopulmonary bypass (CPB). Evidence Rating Level: 1 (Excellent) ARDS is a common postoperative complication after cardiac surgery with CPB, with very high mortality rates. Neutrophil elastase (NE) is a key…