Lyse your cells in 100% formic acid to get 40% more membrane proteins??

Okay. Chemically I do not understand why this would work. That's okay, I don't understand how a lot of things work.... They start out by laser capture microdissecting a pretty big area of cells. Something like 500 micron x 500 in 15 micron cuts. And you stop wondering why the cut is that big when you see the digests are loaded on a Q Exactive Classic. Man, I love those old things, but proteomics…