Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in <i>Caenorhabditis elegans</i>

While aging is the greatest risk factor for the development of neurodegenerative disease, the role of aging in these diseases is poorly understood. Our previous work has shown that targeting aging pathways can be neuroprotective in animal models of neurodegenerative disease. Based on these findings, we believe that by gaining insight into the aging process that knowledge can be applied to identify…