Parkinson’s disease-associated <i>PINK1</i> loss disrupts ensheathing glia and causes dopaminergic neuron synapse loss

Parkinson’s disease (PD) is commonly associated with the loss of dopaminergic neurons in the substantia nigra , but many other cell types are affected even before neuron loss occurs. Recent studies have linked oligodendrocytes to early stages of PD, though their precise role is still unclear. PINK1 is mutated in familial PD, and through unbiased single-cell sequencing of the entire brain of…