Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey

The KCNE (KCNE1–6) proteins are single-pass transmembrane auxiliary subunits of the voltage-gated K + channel KCNQ1. KCNQ1–KCNE complexes have been well studied in jawed vertebrates ranging from zebrafish to humans, but KCNE subunits from earlier-diverging vertebrates remain poorly characterized. Here, we functionally characterize a single KCNE-like gene in lamprey, a jawless vertebrate, and…