# pem (blogs) — RSS Amplifier Recent posts from the 3 feeds in the RSS Amplifier directory that cover pem. Page: Feed: --- ## [ME Research UK-funded study detects brain tissue changes in ME/CFS and long COVID](https://www.meresearch.org.uk/me-research-uk-funded-study-detects-brain-tissue-changes-in-me-cfs-and-long-covid/) _2026-08-20 · Emma · (untitled)_ Further ME Research UK-funded research from Dr Leighton Barnden’s team at Griffith University adds to growing evidence that both ME/CFS and long COVID are associated with measurable changes in the brain. Using advanced MRI techniques capable of detecting subtle abnormalities not picked up by standard scans, the team found alterations in brain tissue microstructure in \[…\] ## [Heterogeneity in ME/CFS](https://www.meresearch.org.uk/heterogeneity-in-me-cfs/) _2026-08-19 · Emma · (untitled)_ Last week, in a posting on X, the Simmaron Research Centre, USA (whose institute works to advance translational science in treating neuroimmune diseases) have highlighted that “one of the biggest challenges in ME/CFS research has been patient heterogeneity“. This research group is behind a Rapamycin Pilot Treatment Trial for ME/CFS, and in 2022 published a \[…\] ## [YouTube webinar “How to manage and treat post-exertional malaise (PEM)”](https://www.meresearch.org.uk/youtube-webinar-how-to-manage-and-treat-post-exertional-malaise-pem/) _2026-08-18 · Emma · (untitled)_ Research from Associate Professor Rob Wüst – who has recently published a study, co-funded by ME Research UK, which identifies that muscle problems in long COVID and ME/CFS cannot be explained by prolonged inactivity – was highlighted (around 28 minutes and 50 seconds into the YouTube video) by Professor David Putrino as some of the \[…\] ## [Seven in Ten Long COVID Patients May Have Orthostatic Intolerance. A New Meta-Analysis Finally Puts Numbers on It.](https://dysautonomiadecoded.substack.com/p/seven-in-ten-long-covid-patients) _2026-08-17 · Dysautonomia Decoded · Dysautonomia Decoded_ The first global prevalence estimates of autonomic dysfunction in Long COVID are here. The numbers are larger than most clinicians suspect. ## [Post-exertional malaise (PEM) survey](https://www.meresearch.org.uk/post-exertional-malaise-pem-survey/) _2026-08-15 · Erhun · (untitled)_ Please take a few minutes to complete our short survey and help inform us about your experience of post-exertional malaise (PEM). ## [Post-exertional malaise (PEM) in ME/CFS](https://www.meresearch.org.uk/post-exertional-malaise-pem-in-me-cfs/) _2026-08-15 · Erhun · (untitled)_ Post-exertional malaise (PEM), the cardinal feature of ME/CFS, is particularly debilitating as it involves the amplification of existing symptoms, alongside the potential appearance of new ones, following minimal exertion. However, the term “exertion” may be misconstrued, by those unfamiliar with ME/CFS, as activities typically considered high intensity by healthy individuals. Consequently,… ## [Symptom Saturday – ME Research UK’s new weekly series](https://www.meresearch.org.uk/symptom-saturday-me-research-uks-new-weekly-series/) _2026-08-14 · Erhun · (untitled)_ Tomorrow, we’re kicking off Symptom Saturday – an ongoing series dedicated to taking an in-depth look at one core or additional symptom of ME/CFS at a time. The weekly series will explore relevant research, clinical guidelines, lived experiences, and management (including reference to key comorbidities). Look out for our survey later in the day to \[…\] ## [A Wearable Device Might Be Able to Predict a Crash Before It Happens - A New Study Tested This.](https://dysautonomiadecoded.substack.com/p/a-wearable-device-might-be-able-to) _2026-08-13 · Dysautonomia Decoded · Dysautonomia Decoded_ A 2026 study of 4,244 people with Long COVID, ME/CFS and other chronic conditions found that morning heart rate variability data could predict evening symptom severity with meaningful accuracy. ## [Collaborator on DISCOVER-ME announced](https://www.meresearch.org.uk/collaborator-on-discover-me-announced/) _2026-08-13 · Emma · (untitled)_ An article has been published by Aarhus Universitet announcing that Associate Professor Rikke Katrine Jentoft Olsen from the university’s Department of Clinical Medicine will work alongside Prof. Simon Carding on the DISCOVER-ME research project – a major pan-European research project which represents a significant advance in co-ordinated international biomedical research into the ME/CFS.… ## [Consensus paper on ‘Guidance on Home-Based Care for People with Severe ME/CFS’ published.](https://www.meresearch.org.uk/consensus-paper-on-guidance-on-home-based-care-for-people-with-severe-me-cfs-published/) _2026-08-12 · Emma · (untitled)_ An article entitled “Guidance on Home-Based Care for People with Severe ME/CFS: A Transdisciplinary Expert Statement” has been published. Estimates suggest that around 25% of individuals with ME have the severe form of the disease, and the impact of severe ME on an individual’s life is profound, leaving many confined to their homes, bedbound, or \[…\] ## [AI Summaries & Audio Briefings (Sponsored)](https://crawlproof.com/a/8QUkxoCecUib) _2026-08-12 · **Sponsored**_ Read AI summaries and listen to concise audio briefings for the latest stories. ## ["It's Not PoTS." Doesn't Mean Nothing Is Wrong.](https://dysautonomiadecoded.substack.com/p/its-not-pots-doesnt-mean-nothing) _2026-08-10 · Dysautonomia Decoded · Dysautonomia Decoded_ A 2024 study of 534 ME/CFS patients found that 91% showed abnormal reductions in brain blood flow and cardiac output when upright, despite passing the tilt table test with completely normal results. ## [Scientists Looked Inside the Spinal Fluid of ME/CFS Patients. Those With PoTS Showed Something Different.](https://dysautonomiadecoded.substack.com/p/scientists-looked-inside-the-spinal) _2026-08-08 · Dysautonomia Decoded · Dysautonomia Decoded_ A 2026 study looked directly into the cerebrospinal fluid of ME/CFS patients and found proteins linked to Alzheimer’s, blood clotting and immune activation. Here is what that actually means. ## [Severe ME Day 2026](https://www.meresearch.org.uk/severe-me-day-2026/) _2026-08-08 · Erhun · (untitled)_ Background Severe ME Day – 8th August – is a day dedicated to raising awareness about severe myalgic encephalomyelitis (ME). Estimates suggest that around 25% of individuals with ME suffer from the severe form of the disease. The impact of severe ME on an individual’s life is profound, leaving many confined to their homes, bedbound, or \[…\] ## [Fundraising Focus – August 2026](https://www.meresearch.org.uk/fundraising-focus-august-2026/) _2026-08-06 · Miki · (untitled)_ Each month, Fundraising Focus is our way of saying thank you and celebrate the people behind the fundraising. ## [Your Brain Looks Different If You Have ME/CFS or Long COVID.](https://dysautonomiadecoded.substack.com/p/your-brain-looks-different-if-you) _2026-08-05 · Dysautonomia Decoded · Dysautonomia Decoded_ A study published this month used advanced MRI to map microstructural brain changes in ME/CFS and Long COVID and the findings are hard to dismiss. ## [10 Up and Coming PoTS and Dysautonomia Treatments: What the Research Actually Shows](https://dysautonomiadecoded.substack.com/p/10-up-and-coming-pots-and-dysautonomia) _2026-08-03 · Dysautonomia Decoded · Dysautonomia Decoded_ Lets take a detailed look at 10 treatments currently in trials or emerging evidence, what stage they are at, and what the pros and cons actually are. ## [GLP-1 Medications and PoTS: Here Is What the Evidence Says.](https://dysautonomiadecoded.substack.com/p/glp-1-medications-and-pots-here-is) _2026-07-31 · Dysautonomia Decoded · Dysautonomia Decoded_ Semaglutide improved one patient’s PoTS significantly. Tirzepatide made another dramatically worse. Both are GLP-1 receptor agonists. Here is why that actually makes biological sense. ## [Creatine for ME/CFS and Long COVID: Could a Gym Supplement Actually Help With Post-Exertional Malaise (PEM)?](https://dysautonomiadecoded.substack.com/p/creatine-for-mecfs-and-long-covid) _2026-07-29 · Dysautonomia Decoded · Dysautonomia Decoded_ Creatine has spent decades being associated with gym bags and protein shakes. A growing body of research suggests it might have a role in one of the most debilitating symptoms of ME/CFS and Long COVID ## [Does Having Had COVID Raise Your Cancer Risk?](https://dysautonomiadecoded.substack.com/p/does-having-had-covid-raise-your) _2026-07-27 · Dysautonomia Decoded · Dysautonomia Decoded_ A new research review investigates whether SARS-CoV-2 nudges the body toward cancer biology... and the honest answer is complicated ## [Post-Exertional Malaise (PEM): What Is Actually Happening in Your Body When You Crash](https://dysautonomiadecoded.substack.com/p/post-exertional-malaise-pem-what) _2026-07-26 · Dysautonomia Decoded · Dysautonomia Decoded_ PEM is one of the most debilitating and least understood features of Long COVID, ME/CFS and dysautonomia. New research is finally starting to map the mechanisms. Here is what we know. ## [Earn crypto for idle GPUs (Sponsored)](https://crawlproof.com/a/VpNr1kURs2pO) _2026-07-26 · **Sponsored**_ Run one CLI, host Qwen/Llama/Mistral, and earn BTC, ETH, SOL, or USDC ## [Argumentationsgrundlage zur Post-Exertionellen Malaise (PEM)](https://www.millionsmissing.de/2025/11/08/argumentationsgrundlage-zur-post-exertionellen-malaise-pem/) _2025-11-08 · www.millionsmissing.de Blog Feed_ Kurzüberblick zur Post-Exertionellen Malaise (PEM) Evidenzbasierte Grundlage zur medizinischen und sozialrechtlichen Bewertung von ME/CFS Stand: November 2025 Krankheitsdefinierendes Merkmal Die Post-Exertionelle Malaise (PEM) ist das zentrale und krankheitsdefinierende Merkmal der Erkrankung Myalgische Enzephalomyelitis/Chronisches Fatigue Syndrom (ME/CFS). PEM wird in der Wissenschaft als eine… ## [Lipkin-Studie: Bei ME/CFS reagiert das Immunsystem auf Belastung, als handle es sich um eine Infektion](https://www.millionsmissing.de/2025/09/14/%C3%BCberaktiviertes-immunsystem-und-energiestress-bei-me-cfs-neue-einblicke-aus-der-lipkin-studie/) _2025-09-14 · www.millionsmissing.de Blog Feed_ Kurzzusammenfassung Eine der bisher größten Studien zu ME/CFS liefert neue Einblicke. Das Immunsystem von Betroffenen ist bereits in Ruhe auffällig aktiv, vor allem jedoch nach körperlicher Belastung zeigt sich die entscheidende Fehlsteuerung. Selbst geringe Anstrengungen lösen übersteigerte Entzündungsreaktionen und Energiestress in den Zellen aus. Untersucht wurden über 200 Personen. Die… ## [Antikörper im Fokus: Vom ‚Faktor X‘ im Blut zum Schlüsselfaktor IgG bei ME/CFS und Post-COVID](https://www.millionsmissing.de/2025/08/22/antik%C3%B6rper-im-fokus-vom-faktor-x-im-blut-zum-schl%C3%BCsselfaktor-igg-bei-me-cfs-und-post-covid/) _2025-08-22 · www.millionsmissing.de Blog Feed_ Kurzzusammenfassung Seit Jahren berichten Studien, dass im Blut von ME/CFS - und Post-COVID-Betroffenen etwas vorhanden ist, das gesunde Zellen verändert. Doch der Auslöser blieb unklar. Eine neue Arbeit von Bhupesh Prusty et al. liefert nun erstmals eine präzise Antwort: IgG-Antikörper, die aus Patientenblut isoliert wurden, reichen allein aus, um in Endothelzellen mitochondriale Fragmentierung… ## [DecodeME: Acht genetische Spuren zu ME/CFS](https://www.millionsmissing.de/2025/08/17/decodeme-acht-genetische-spuren-zu-me-cfs/) _2025-08-17 · www.millionsmissing.de Blog Feed_ Kurzzusammenfassung Zum ersten Mal haben Forschende genetische Koordinaten für ME/CFS identifiziert. Acht klare Signale betreffen Immun- und Nervensystem. Die Studie im Überblick Am 6. August 2025 veröffentlichte das DecodeME-Team einen Preprint mit den ersten Ergebnissen der größten genetischen Untersuchung zu ME/CFS. Insgesamt nahmen 15.579 Betroffene und 259.909 Kontrollpersonen teil. Damit… ## [ME/CFS: Neue PET-Daten zeigen entzündetes Gehirn](https://www.millionsmissing.de/2025/08/11/me-cfs-neue-pet-daten-zeigen-entz%C3%BCndetes-gehirn/) _2025-08-11 · www.millionsmissing.de Blog Feed_ Der US-Forscher Jarred Younger hat erstmals mit einem modernen PET-Tracer (\[^18F\]-DPA-714) großflächige Aktivierung von Mikroglia, den Immunzellen des Gehirns, bei ME/CFS sichtbar gemacht. Die Ergebnisse wurden im August 2025 erstmals öffentlich vorgestellt, sind noch nicht peer-reviewed und gelten daher als vorläufig. Anders als MRT, das nur indirekt Entzündungsfolgen sichtbar macht, kann PET… ## [„Mechanismen der Post-Exertional Malaise (PEM)“ – Prof. Christian Puta](https://www.millionsmissing.de/2025/05/21/mechanismen-der-post-exertional-malaise-pem-prof-christian-puta/) _2025-05-21 · www.millionsmissing.de Blog Feed_ Kurzzusammenfassung In seinem Vortrag auf der Int. ME/CFS Conference 2025 stellte Prof. Christian Puta zentrale Erkenntnisse zu den pathophysiologischen Mechanismen der Post-Exertional Malaise (PEM) vor – dem Hauptmerkmal von ME/CFS . PEM bezeichnet eine verzögerte, anhaltende Verschlechterung verschiedener Symptome nach körperlicher, kognitiver, emotionaler, orthostatischer (aufrechter) oder… ## [PEM ist messbar: „Veränderungen der Skelettmuskulatur bei Post-COVID-Syndrom und ME/CFS“ | Dr. Rob Wüst](https://www.millionsmissing.de/2025/05/18/ver%C3%A4nderungen-der-skelettmuskulatur-bei-post-covid-syndrom-und-me-cfs-dr-rob-w%C3%BCst/) _2025-05-18 · www.millionsmissing.de Blog Feed_ Kurzzusammenfassung Post-Exertional Malaise (PEM) ist das charakteristische Hauptmerkmal von ME/CFS und wird vermehrt auch bei Long COVID als zentrales Merkmal beschrieben. In der Studie von Dr. Rob Wüst jedoch erfüllten alle untersuchten Betroffenen die kanadischen Konsenskriterien (CCC) , einschließlich PEM. Die sogenannte „Long-COVID-Kohorte“ unterscheidet sich von der ME/CFS-Kohorte… ## [Broken Bridge Syndrome: Ein neues Verständnis und diagnostischer Marker für das Post-COVID-Syndrom (PCS) und ME/CFS?](https://www.millionsmissing.de/2025/04/14/broken-bridge-syndrome-ein-neues-verst%C3%A4ndnis-und-diagnostischer-marker-f%C3%BCr-das-post-covid-syndrom-pcs-und-myalgische-enzephalomyelitis-chronisches-fatigue-sy/) _2025-04-14 · www.millionsmissing.de Blog Feed_ Kurzbeschreibung Das Broken Bridge Syndrome beschreibt eine strukturelle und funktionelle Entkopplung zwischen Hirnstamm und Kleinhirn – insbesondere im Bereich der cerebellären Pedunculi – und wurde erstmals vom Hamburger Wissenschaftler Dr. Christof Ziaja im Kontext vom Post-COVID-Syndrom (PCS) identifiziert. Die cerebellären Pedunculi kann man sich vorstellen wie mehrspurige Datenautobahnen im… ## [Stationärer Krankenhausaufenthalt: Besonderheiten und Anforderungen bei ME/CFS](https://www.millionsmissing.de/2025/01/23/station%C3%A4rer-krankenhausaufenthalt-besonderheiten-und-anforderungen-bei-me-cfs/) _2025-01-23 · www.millionsmissing.de Blog Feed_ Leitfaden für medizinisches Fachpersonal Definition und Auslöser von ME/CFS Die Myalgische Enzephalomyelitis/Chronisches Fatigue Syndrom (ME/CFS) , ICD-10-Code: G93.3, ist eine schwerwiegende, chronische Multisystemerkrankung, die häufig nach Infektionen wie Influenza, infektiöser Mononukleose (Pfeiffersches Drüsenfieber) oder COVID-19 auftritt. Auch andere Auslöser , wie chirurgische Eingriffe,… ## [Countdown to Getting Paid (Sponsored)](https://crawlproof.com/a/zVk2fkK5sqeo) _2025-01-23 · **Sponsored**_ Create a shareable wallet timer — deposits buy back time and pay debt down ## [Anästhesieleitfaden bei ME/CFS: Empfohlene Verfahren und Prävention](https://www.millionsmissing.de/2025/01/16/an%C3%A4sthesieleitfaden-bei-me-cfs-empfohlene-verfahren-und-pr%C3%A4vention/) _2025-01-16 · www.millionsmissing.de Blog Feed_ Kurzeinführung zu ME/CFS und PEM Was ist ME/CFS? Die Myalgische Enzephalomyelitis/Chronisches Fatigue Syndrom (ME/CFS ), ICD-10-Code: G93.3, ist eine komplexe, chronische Multisystemerkrankung. Sie tritt häufig nach Infektionen wie Influenza, infektiöser Mononukleose, COVID-19 oder anderen Triggern wie Operationen und gelegentlich nach Impfungen auf. ME/CFS betrifft das zentrale und autonome…