AIRE: The Orchestrator of Self-Tolerance

Part I Part II (you are reading this) Part III Your immune system is a powerful guard dog, but it needs training. From the moment you are born, it has to learn the difference between intruders and you. Most of us never notice that training happening. But in rare cases, the lesson plan goes unexpectedly wrong, and the immune system grows up confused, lashing out at the body while letting some…