DepMap in the Upside Down: When Tumor Suppressors Reveal Hidden Vulnerabilities

People (including me) usually come to DepMap for the synthetic lethalities, the strongly selective dependencies, and the extremely negative gene effect scores (often CERES/Chronos < -1) that scream “this gene is essential for this cell line”; but I have recently found that there is an “Upside Down” view of the data set that is easy to miss. This reversed view is anchored based on a handful of…