Revisiting My PALI-2108 Tissue Penetration Model In Fibrostenotic Crohn's Disease After Phase 1b Readout

My reaction-diffusion model tried to answer whether the active metabolite of PALI-2108 could penetrate Crohn's strictures but rested on untested assumptions. Phase 1b ileal pharmacokinetics, pharmacodynamics, and endoscopic data from five fibrostenotic Crohn's patients update the priors.