Computational Simulation Of Four Non-Covalent KRAS G12D Inhibitors Suggests Verastem's VS-7375 May Achieve The Deepest Signaling Suppression

Computational simulation of KRAS G12D conformational cycling across VS-7375, BBO-11818, HRS-4642, and INCB161734 under within-cycle and multi-day dosing suggests VS-7375 may reach 90% suppression at the lowest free drug concentration.