# obstetrics (blogs) — RSS Amplifier Recent posts from the 7 feeds in the RSS Amplifier directory that cover obstetrics. Page: Feed: --- ## [Brain-predicted age difference may reliably predict dementia progression](https://www.2minutemedicine.com/brain-predicted-age-difference-may-reliably-predict-dementia-progression/) _2026-08-19 · Paary Balakumar · 2 Minute Medicine_ 1. Brain-predicted age difference (brain-PAD) is a robust, reproducible predictor of dementia progression across two independent estimation methods, and it is most clinically useful in subjective cognitive decline, where it can help identify low-risk patients and reassure the “worried well,” rather than in mild cognitive impairment, where visual rating scales already capture most prognostically… ## [Diffusion-weighted imaging may aid in prognostication for intracerebral hemorrhage](https://www.2minutemedicine.com/diffusion-weighted-imaging-may-aid-in-prognostication-for-intracerebral-hemorrhage/) _2026-08-18 · Paary Balakumar · 2 Minute Medicine_ 1. Diffusion-weighted imaging (DWI)-positive lesions are common after intracerebral hemorrhage (ICH) and serve as an independent biomarker of cerebral small vessel disease (cSVD) severity and worse 6-month functional outcome, supporting their potential use in prognostication and clinical trial patient selection. 2. The anatomical distribution of DWI-positive lesions may help distinguish cerebral… ## [A neurostimulation intervention may improve pain in patients with chronic low back pain](https://www.2minutemedicine.com/a-neurostimulation-intervention-may-improve-pain-in-patients-with-chronic-low-back-pain/) _2026-08-17 · Paary Balakumar · 2 Minute Medicine_ 1. Restorative neurostimulation produces durable, clinically meaningful improvements in pain, disability, and quality of life at 5 years in real-world chronic mechanical low back pain patients. Evidence Rating Level: 3 (Average) This 5-year follow-up study evaluated restorative neurostimulation (ReActiv8) for chronic mechanical low back pain (CLBP) attributed to multifidus dysfunction. Restorative… ## [2 Minute Medicine Rewind August 17, 2026](https://www.2minutemedicine.com/2-minute-medicine-rewind-august-17-2026/) _2026-08-17 · Paary Balakumar · 2 Minute Medicine_ The impact of short-term reduction in hepatic triglycerides on vascular health in adults with or at risk of metabolic dysfunction-associated steatotic liver disease 1. Short-term dietary weight loss targeting hepatic fat reduction was associated with measurable improvements in arterial stiffness, endothelial function, and cardiovascular risk scores in MASLD patients. 2. These vascular improvements… ## [Melatonin use is associated with lower proportions of rapid eye movement sleep in children](https://www.2minutemedicine.com/melatonin-use-is-associated-with-lower-proportions-of-rapid-eye-movement-sleep-in-children/) _2026-08-14 · Alex Xiang · 2 Minute Medicine_ 1. In an observational study of pediatric patients, melatonin use may be associated with a decreased percentage of rapid eye movement (REM) sleep compared to melatonin nonusers. Evidence Rating Level: 2 (Good) Melatonin has been used by up to 19% of pediatric patients in the past 30 days. It is available without a prescription, and \[…\] The post Melatonin use is associated with lower proportions of… ## [Tumour microenvironment factors may influence cancer progression and response to tamoxifen (Nolvadex) in patients with estrogen receptor-positive and human epidermal growth factor receptor 2 breast cancer](https://www.2minutemedicine.com/tumour-microenvironment-factors-may-influence-cancer-progression-and-response-to-tamoxifen-nolvadex-in-patients-with-estrogen-receptor-positive-and-human-epidermal-growth-factor-receptor-2-breast-ca/) _2026-08-13 · Alex Xiang · 2 Minute Medicine_ 1. In patients with estrogen receptor (ER)+ and human epidermal growth factor receptor 2 (HER2)- breast cancer, certain tumour microenvironments (TMEs) were associated with improved breast cancer progression and treatment response to tamoxifen (Nolvadex). Evidence Rating Level: 1 (Excellent) The TME of tumour, immune, and stromal cells varies depending on breast cancer estrogen receptor status.… ## [A health coaching intervention may improve blood pressure control in postpartum women](https://www.2minutemedicine.com/a-health-coaching-intervention-may-improve-blood-pressure-control-in-postpartum-women/) _2026-08-12 · Alex Xiang · 2 Minute Medicine_ 1. A health coaching intervention combined with self-measured blood pressure (SMBP) monitoring for postpartum women was associated with significantly greater engagement with primary care and significantly greater reductions in systolic and diastolic blood pressure (BP). Evidence Rating Level: 1 (Excellent) Hypertensive disorders of pregnancy (HDP) affect up to 16% of pregnancies in the United… ## [Surgery is associated with an increased quality of life in women with endometriosis](https://www.2minutemedicine.com/surgery-is-associated-with-an-increased-quality-of-life-in-women-with-endometriosis/) _2026-08-11 · Alex Xiang · Surgery | 2 Minute Medicine_ 1. In adult women with endometriosis, surgery was associated with an increased quality of life independent of their #Enzian classification. Evidence Rating Level: 2 (Good) Endometriosis affects 7-10% of women of reproductive age and has a heterogeneous presentation, ranging from superficial peritoneal implants to involvement of retroperitoneal structures. The wide range of symptoms associated with… ## [Bougie-guided and stylet-guided intubation may have similar success rate in the intubation of trauma patients](https://www.2minutemedicine.com/bougie-guided-and-stylet-guided-intubation-may-have-similar-success-rate-in-the-intubation-of-trauma-patients/) _2026-08-11 · Alex Xiang · 2 Minute Medicine_ 1. In critically injured trauma patients with difficult airways, there were no statistically significant differences in first-pass success between bougie-guided and stylet-guided intubation. Evidence Rating Level: 1 (Excellent) First-pass intubation failure during emergency airway management is associated with hypoxia, aspiration, hemodynamic instability, and cardiac arrest. This is particularly… ## [Joint fusion superior to watchful waiting for hallux rigidus](https://www.2minutemedicine.com/joint-fusion-superior-to-watchful-waiting-for-hallux-rigidus/) _2026-08-10 · Adrian Wong · 2 Minute Medicine_ 1. In this randomized controlled trial, arthrodesis significantly reduced walking-related pain compared with watchful waiting in adults aged 40 years or older with hallux rigidus. 2. Arthrodesis also improved pain at rest and was associated with lower analgesic use. Evidence Rating Level: 1 (Excellent) Study Rundown: Hallux rigidus, or osteoarthritis of the first metatarsophalangeal joint \[…\] The… ## [AI Summaries & Audio Briefings (Sponsored)](https://crawlproof.com/a/8QUkxoCecUib) _2026-08-10 · **Sponsored**_ Read AI summaries and listen to concise audio briefings for the latest stories. ## [Perioperative toripalimab improves event-free survival in non-small cell lung cancer](https://www.2minutemedicine.com/perioperative-toripalimab-improves-event-free-survival-in-non-small-cell-lung-cancer/) _2026-08-09 · Clare Sun · Surgery | 2 Minute Medicine_ 1. In patients with resectable stage III non-small cell lung cancer, perioperative toripalimab plus chemotherapy increased rates of tumor and lymph node downstaging and improved event-free survival compared to chemotherapy alone. 2. Operative approach, complete resection, hospital stay, and perioperative complication rates remained comparable between study groups. Evidence Rating Level: 1… ## [Antithrombotic agents may be effective in preventing migraine in patients with patent foramen ovale](https://www.2minutemedicine.com/antithrombotic-agents-may-be-effective-in-preventing-migraine-in-patients-with-patent-foramen-ovale/) _2026-08-07 · Siwen Liu · Chronic Disease | 2 Minute Medicine_ 1. The antithrombotic agents aspirin, clopidogrel, and rivaroxaban were non-inferior to metoprolol for responder rate in participants with patent foramen ovale and migraine. Evidence Rating Level: 1 (Excellent) Patent foramen ovale (PFO) has been associated with migraine and has been suggested to involve a microembolic mechanism. Antithrombotic treatment has been proposed for migraine prevention… ## [Active surveillance is cost-effective compared with standard surgery among esophageal cancer patients with complete clinical response after neoadjuvant chemoradiotherapy](https://www.2minutemedicine.com/active-surveillance-is-cost-effective-compared-with-standard-surgery-among-esophageal-cancer-patients-with-complete-clinical-response-after-neoadjuvant-chemoradiotherapy/) _2026-08-06 · Siwen Liu · Surgery | 2 Minute Medicine_ 1. Active surveillance was cost-effective over 5 years compared with standard surgery in patients with esophageal cancer and complete clinical response after neoadjuvant chemoradiotherapy. Evidence Rating Level: 1 (Excellent) Active surveillance for patients with esophageal cancer and a complete clinical response (CCR) after neoadjuvant chemoradiotherapy (nCRT) is noninferior to standard surgery… ## [Intraarterial dexamethasone may be effective for pain relief following uterine fibroid embolization](https://www.2minutemedicine.com/intraarterial-dexamethasone-may-be-effective-for-pain-relief-following-uterine-fibroid-embolization/) _2026-08-05 · Siwen Liu · Surgery | 2 Minute Medicine_ 1. Intraarterial dexamethasone was associated with greater pain relief after uterine fibroid embolization compared with placebo. Evidence Rating Level: 1 (Excellent) Uterine fibroid embolization (UFE) is a minimally invasive treatment for symptomatic uterine fibroids, which are most common tumor of the female reproductive tract. However, a major limitation of UFE is acute postprocedural pain.… ## [Hematologic inflammatory indices may predict prognosis in younger patients with COVID-19 but not older patients](https://www.2minutemedicine.com/hematologic-inflammatory-indices-may-predict-prognosis-in-younger-patients-with-covid-19-but-not-older-patients/) _2026-08-04 · Siwen Liu · Chronic Disease | 2 Minute Medicine_ 1. Hematologic inflammatory indices in emergency department patients with COVID-19 showed an age-dependent prognostic performance for 30-day mortality, with systemic immune-inflammation index showing good discriminatory performance in patients \<65 years and poorer performance in patients \>65 years. Evidence Rating Level: 2 (Good) Hematologic markers derived from the complete blood count (CBC)… ## [Younger age and systemic metastases may independently predict survival among patients with choroidal metastases](https://www.2minutemedicine.com/younger-age-and-systemic-metastases-may-independently-predict-survival-among-patients-with-choroidal-metastases/) _2026-08-03 · Siwen Liu · Chronic Disease | 2 Minute Medicine_ 1. Younger age (\<59.6 years) and systemic metastases (\>1) were independent predictors of survival among patients with choroidal metastases. Evidence Rating Level: 2 (Good) Around 1–2% of all cancer patients develop intraocular metastases, with the choroid representing the primary site of metastatic involvement (90%). It is unclear how age and primary tumor type impact survival \[…\] The post Younger… ## [A digital mental health intervention may improve anxiety in breast cancer survivors](https://www.2minutemedicine.com/a-digital-mental-health-intervention-may-improve-anxiety-in-breast-cancer-survivors/) _2026-07-31 · Lori Lai · Psychiatry | 2 Minute Medicine_ 1. Among a large cohort of breast cancer survivors, those who participated in digital mental health treatment reported a reduction in symptoms of anxiety, with additional human coaching associated with a reduction in depression. Evidence Rating Level: 1 (Excellent) Almost 50% of all women suffering from advanced breast cancer experience significant anxiety and depression within \[…\] The post A… ## [Use of semaglutide for weight control among women of reproductive age is more common in those using hormonal contraception](https://www.2minutemedicine.com/use-of-semaglutide-for-weight-control-among-women-of-reproductive-age-is-more-common-in-those-using-hormonal-contraception/) _2026-07-30 · Lori Lai · Obstetrics | 2 Minute Medicine_ 1. Among a nested case-control study, use of hormonal contraception was associated with higher subsequent semaglutide initiation for weight control among women of reproductive age. Evidence Rating Level: 1 (Excellent) Weight changes and metabolic symptoms are common side effects associated with hormonal contraception available for women of reproductive age. In patients where these changes are \[…\]… ## [A cognitive rehabilitation program may improve cognitive performance in patients with long COVID](https://www.2minutemedicine.com/a-cognitive-rehabilitation-program-may-improve-cognitive-performance-in-patients-with-long-covid/) _2026-07-28 · Lori Lai · Psychiatry | 2 Minute Medicine_ 1. In a multicenter, single-blind, randomized clinical trial, participation in a cognitive rehabilitation program improved goal attainment and cognitive test scores in patients suffering from Long COVID-related cognitive dysfunction. Evidence Rating Level: 1 (Excellent) Long COVID is defined as a chronic condition that occurs following the infection of COVID-19, present for at least 3 months \[…\]… ## [Medical or procedural abortion may not increase risk of psychotropic medication use after five years](https://www.2minutemedicine.com/medical-or-procedural-abortion-may-not-increase-risk-of-psychotropic-medication-use-after-five-years/) _2026-07-27 · Lori Lai · Psychiatry | 2 Minute Medicine_ 1. Among a Danish population-based cohort study, increased initiation of psychotropic medication in the first year following both medical and procedural methods of abortion were found, with decreased risk of initiation of psychotropic medication within five or more years following both medical and procedural abortions. Evidence Rating Level: 2 (Good) There is limited research on \[…\] The post… ## [Earn crypto for idle GPUs (Sponsored)](https://crawlproof.com/a/VpNr1kURs2pO) _2026-07-27 · **Sponsored**_ Run one CLI, host Qwen/Llama/Mistral, and earn BTC, ETH, SOL, or USDC ## [A medical care at home program following hospitalization with acute decompensated heart failure may offer a safe and effective alternative to continued hospitalization](https://www.2minutemedicine.com/a-medical-care-at-home-program-following-hospitalization-with-acute-decompensated-heart-failure-may-offer-a-safe-and-effective-alternative-to-continued-hospitalization/) _2026-07-24 · Simon Pan · Cardiology | 2 Minute Medicine_ 1. Following hospitalization for acute decompensated heart failure (HF), there was no difference in all-cause readmissions and mortality between patients treated with an advanced medical care at home (AMCAH) program compared with brick-and-mortar (BAM) hospitalization. Evidence Rating Level: 2 (Good) Acute hospital care at home programs have seen a dramatic increase in implementation since the \[…\]… ## [Catheter ablation within 1 year of atrial fibrillation diagnosis is associated with reduced risk of recurrence](https://www.2minutemedicine.com/catheter-ablation-within-1-year-of-atrial-fibrillation-diagnosis-is-associated-with-reduced-risk-of-recurrence/) _2026-07-24 · Simon Pan · Cardiology | 2 Minute Medicine_ 1. Patients with atrial fibrillation (AF) treated with catheter ablation 1 to 4 years after AF diagnosis had a 48% higher chance of AF recurrence compared to those treated within 1 year. 2. Patients with atrial fibrillation (AF) treated with catheter ablation 5 years or greater after AF diagnosis had a 110% higher chance of \[…\] The post Catheter ablation within 1 year of atrial fibrillation… ## [Epidural analgesia in labour is not associated with adverse neonatal health outcomes](https://www.2minutemedicine.com/epidural-analgesia-in-labour-is-not-associated-with-adverse-neonatal-health-outcomes/) _2026-07-23 · Simon Pan · Obstetrics | 2 Minute Medicine_ 1. Epidural analgesia in labour is not associated with significant risk of neonatal neurological morbidity, neonatal morbidity or mortality. Evidence Rating Level: 2 (Good) Epidural analgesia during labour is regarded as the most effective form of pain control, which is important given that poor pain control may lead to physiological stress in mothers with important \[…\] The post Epidural analgesia… ## [Intermittent metformin (Glucophage) is non-inferior to continuous metformin for prediabetes in post-partum women with prior gestational diabetes mellitus](https://www.2minutemedicine.com/intermittent-metformin-glucophage-is-non-inferior-to-continuous-metformin-for-prediabetes-in-post-partum-women-with-prior-gestational-diabetes-mellitus/) _2026-07-21 · Simon Pan · Obstetrics | 2 Minute Medicine_ 1. Among women with prediabetes following prior gestational diabetes mellitus (GDM), intermittent metformin (Glucophage) in combination with lifestyle modifications was non-inferior to continuous metformin in combination with lifestyle modifications. Evidence Rating Level: 1 (Excellent) Women with GDM are at a significantly increased risk of developing type 2 diabetes mellitus (T2DM) postpartum… ## [2MM: AI Roundup: NHS England expands Microsoft Copilot nationwide, ARPA-H advances autonomous cardiovascular AI, FDA advisors back Moderna’s mRNA influenza vaccine, and UpDoc earns first clearance for a patient-facing large language model](https://www.2minutemedicine.com/2mm-ai-roundup-food-and-drug-administration-reviews-liver-injury-prediction-tool-joint-commission-launches-healthcare-artificial-intelligence-certification-governance-playbooks-aim-to-standardize-2/) _2026-07-20 · Deepti Shroff · Pediatrics | 2 Minute Medicine_ NHS England is rolling out Microsoft Copilot to 505,000 clinicians after a 30,000-person trial saved nearly an hour of admin time per day Recently, NHS England announced it will deploy Microsoft 365 Copilot to 505,000 clinicians and support staff, following a nine-month pilot across 30,000 workers at 90 NHS organizations. The headline result from that \[…\] The post 2MM: AI Roundup: NHS England… ## [Erector spinae plane blocks may not provide meaningful benefit over standard analgesia in breast surgery patients](https://www.2minutemedicine.com/erector-spinae-plane-blocks-may-not-provide-meaningful-benefit-over-standard-analgesia-in-breast-surgery-patients/) _2026-07-17 · Paary Balakumar · Surgery | 2 Minute Medicine_ 1. Erector spinae plane blocks reduced PACU opioid requirements and modestly shortened PACU stay, but did not produce a clinically meaningful reduction in total opioid consumption over 24 hours. 2. Pain control and patient satisfaction were comparable between groups, suggesting ESP blocks offer limited added analgesic benefit over standard analgesia alone in this setting. Evidence \[…\] The post… ## [Duodenal-jejunal bypass liners may improve glycemic control in patients with diabetes](https://www.2minutemedicine.com/duodenal-jejunal-bypass-liners-may-improve-glycemic-control-in-patients-with-diabetes/) _2026-07-17 · Alexander Uriarte · Surgery | 2 Minute Medicine_ 1. Duodenal-jejunal bypass liners were superior to sham in reducing HbA1c and improved weight loss in patients with uncontrolled type 2 diabetes mellitus. 2. Despite efficacious outcomes, duodenal-jejunal bypass liners raised safety concerns, including a high rate of hepatic abscess. Evidence Rating Level: 1 (Excellent) Study Rundown: A duodenal-jejunal bypass liner (DJBL) is a removable \[…\] The… ## [Spinal instability may be the primary cause of pain in sacral metastases as opposed to neurologic compromise](https://www.2minutemedicine.com/spinal-instability-may-be-the-primary-cause-of-pain-in-sacral-metastases-as-opposed-to-neurologic-compromise/) _2026-07-14 · Paary Balakumar · Surgery | 2 Minute Medicine_ 1. Although neurological symptoms (motor deficits, sensory impairment) were more frequent in patients with sitting-related sacral pain on univariate comparison, this association did not hold in multivariable analysis (aOR 0.83, 95% CI 0.21–2.95, p=0.780), indicating spinal instability—not neurological compromise—was the primary driver of this pain. 2. Patients with sitting-related sacral pain had… ## [Cryoanalgesia increases neuropathic pain after minimally invasive thoracic surgery](https://www.2minutemedicine.com/cryoanalgesia-increases-neuropathic-pain-after-minimally-invasive-thoracic-surgery/) _2026-07-14 · Clare Sun · Surgery | 2 Minute Medicine_ 1. Adults who received cryoanalgesia during minimally invasive thoracic surgery experienced higher neuropathic pain scores at three, six, and twelve months compared to those receiving standard intercostal nerve block alone. 2. Cryoanalgesia and younger age were both associated with increased neuropathic pain risk at one year. Evidence Rating Level: 1 (Excellent) Study Rundown: Minimally invasive… ## [Infection risk with infliximab (Remicade) and adalimumab (Humira) is similar in pediatric inflammatory bowel disease](https://www.2minutemedicine.com/infection-risk-with-infliximab-remicade-and-adalimumab-humira-is-similar-in-pediatric-inflammatory-bowel-disease/) _2026-07-14 · Siwen Liu · Pediatrics | 2 Minute Medicine_ 1. Among children with inflammatory bowel disease, there were no significant differences in serious or outpatient infection risk between initiating infliximab (Remicade) and adalimumab (Humira). Evidence Rating Level: 2 (Good) Study Rundown: Pediatric Inflammatory Bowel Disease (IBD) includes Crohn disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U), and its prevalence is… ## [Countdown to Getting Paid (Sponsored)](https://crawlproof.com/a/zVk2fkK5sqeo) _2026-07-14 · **Sponsored**_ Create a shareable wallet timer — deposits buy back time and pay debt down ## [Septoplasty is more costly but more effective than medical management for deviated septum](https://www.2minutemedicine.com/septoplasty-is-more-costly-but-more-effective-than-medical-management-for-deviated-septum/) _2026-07-13 · Paary Balakumar · Surgery | 2 Minute Medicine_ 1. Immediate septoplasty is more costly but more clinically effective than medical management for deviated septum. 2. Over a 24-month horizon, immediate septoplasty becomes highly likely to be cost-effective, whereas its value at 12 months remains uncertain and sensitive to surgical costing methods. Evidence Rating Level: 1 (Excellent) Deviated nasal septum is commonly managed with \[…\] The post… ## [One-third of US health centers lack onsite prenatal care](https://www.2minutemedicine.com/one-third-of-us-health-centers-lack-onsite-prenatal-care/) _2026-07-13 · Adrian Wong · Obstetrics | 2 Minute Medicine_ 1. In this cross-sectional study, one-third of federally qualified health centers (FQHCs) in the United States did not provide onsite prenatal care and instead referred pregnant patients to external providers. 2. FQHCs without onsite prenatal care were more likely to be located in maternity deserts, highlighting persistent geographic disparities in access to prenatal care. Evidence \[…\] The post… ## [Glucosamine Linked to Faster Alzheimer’s Progression in Patients with Mild Cognitive Impairment](https://www.2minutemedicine.com/glucosamine-linked-to-faster-alzheimers-progression-in-patients-with-mild-cognitive-impairment/) _2026-07-10 · Deepti Shroff · Psychiatry | 2 Minute Medicine_ 1. University of Florida researchers found that glucosamine, the popular joint supplement taken by tens of millions of older Americans, is associated with a 25% higher likelihood of progressing from mild cognitive impairment to Alzheimer’s disease. 2. The proposed mechanism is biochemically plausible: glucosamine is a sugar-related molecule that crosses the blood-brain barrier and appears \[…\] The… ## [Home transvaginal ultrasound is preferred to in-clinic ultrasound and is associated with similar accuracy](https://www.2minutemedicine.com/home-transvaginal-ultrasound-is-preferred-to-in-clinic-ultrasound-and-is-associated-with-similar-accuracy/) _2026-07-09 · Alex Xiang · Obstetrics | 2 Minute Medicine_ 1. At-home transvaginal ultrasonography is clinically accurate compared to in-clinic ultrasonography, preferred by patients, and not associated with an increased incidence of side effects. Evidence Rating Level: 2 (Good) Transvaginal ultrasonography is a safe and invaluable diagnostic tool. However, its sensitive and invasive nature poses a barrier to care, particularly for specific populations,… ## [The association between parental and offspring body mass index may be due to genetic confounding](https://www.2minutemedicine.com/the-association-between-parental-and-offspring-body-mass-index-may-be-due-to-genetic-confounding/) _2026-06-30 · Siwen Liu · Pediatrics | 2 Minute Medicine_ 1. The association between parental body mass index (BMI) and offspring BMI from age 6 months to 8 years may primarily be due to genetic confounding. Evidence Rating Level: 2 (Good) Although parental body mass index (BMI) has been associated with offspring adiposity in childhood, the mechanisms behind this relationship remain unclear. This study thus \[…\] The post The association between parental… ## [2MM: AI Roundup: Food and Drug Administration reviews liver injury prediction tool, Joint Commission launches healthcare artificial intelligence certification, governance playbooks aim to standardize adoption, and pediatric hospitals bring generative tools to the frontline](https://www.2minutemedicine.com/2mm-ai-roundup-food-and-drug-administration-reviews-liver-injury-prediction-tool-joint-commission-launches-healthcare-artificial-intelligence-certification-governance-playbooks-aim-to-standardize/) _2026-06-15 · Deepti Shroff · Pediatrics | 2 Minute Medicine_ Food and Drug Administration reviews artificial intelligence tool for liver injury prediction The Food and Drug Administration (FDA) is reviewing an artificial intelligence based drug development tool designed to predict drug induced liver injury, one of the more stubborn safety problems in clinical development. The agency’s Center for Drug Evaluation and Research accepted a letter \[…\] The post… ## [Children conceived through infertility treatments may have similar growth compared to naturally conceived children](https://www.2minutemedicine.com/children-conceived-through-infertility-treatments-may-have-similar-growth-compared-to-naturally-conceived-children/) _2026-06-11 · Siwen Liu · Obstetrics | 2 Minute Medicine_ 1. After accounting for plurality, children conceived through infertility treatments showed similar growth trajectories to those conceived naturally. Evidence Rating Level: 2 (Good) Compared to children conceived naturally, children conceived through medically assisted reproduction (MAR) may experience different birth outcomes and growth patterns. However, evidence on long-term growth trajectories… ## [Two scores for risk stratification of adults presenting with syncope may be effective at identifying those with low risk](https://www.2minutemedicine.com/two-scores-for-risk-stratification-of-adults-presenting-with-syncope-may-be-effective-at-identifying-those-with-low-risk/) _2026-05-29 · Alex Xiang · Cardiology | 2 Minute Medicine_ 1. The Canadian Syncope Risk Score (CSRS) and FAINT score are effective at identifying which adult patients presenting to the emergency department (ED) are at low risk for short-term adverse outcomes. Evidence Rating Level: 2 (Good) Syncope and presyncope account for 2-3% of all ED visits, with approximately 10% of these patients having serious underlying \[…\] The post Two scores for risk… ## [A novel therapy targeting γ-aminobutyric acid is safe and may be effective in major depressive disorder](https://www.2minutemedicine.com/a-novel-therapy-targeting-%ce%b3-aminobutyric-acid-is-safe-and-may-be-effective-in-major-depressive-disorder/) _2026-05-27 · Alex Xiang · Psychiatry | 2 Minute Medicine_ 1. H3-10353, a novel γ-aminobutyric acid (GABA) positive allosteric modulator, is safe and well-tolerated in healthy patients and those with major depressive disorder (MDD), and demonstrated some therapeutic benefits in a phase 1 clinical trial. Evidence Rating Level: 1 (Excellent) Although there are numerous classes of medications for depression, these treatments result in remission in \[…\] The… ## [Selective serotonin reuptake inhibitors may reduce risk of total joint arthroplasty in osteoarthritis](https://www.2minutemedicine.com/selective-serotonin-reuptake-inhibitors-may-reduce-risk-of-total-joint-arthroplasty-in-osteoarthritis/) _2026-05-21 · Paary Balakumar · Psychiatry | 2 Minute Medicine_ 1. Initiation of centrally acting analgesics in patients with osteoarthritis (OA) was associated with a higher long-term risk of total joint arthroplasty compared with SSRI initiation. 2. Management of comorbid depression may play an important role in OA symptom progression and surgical outcomes, potentially exceeding the benefit of centrally mediated analgesic effects alone. Evidence Rating \[…\]… ## [Adverse pregnancy outcomes is associated with worse offspring cardiovascular health in early adulthood](https://www.2minutemedicine.com/adverse-pregnancy-outcomes-is-associated-with-worse-offspring-cardiovascular-health-in-early-adulthood/) _2026-05-18 · Siwen Liu · Cardiology | 2 Minute Medicine_ 1. Exposure to adverse pregnancy outcomes, particularly hypertensive disorders of pregnancy, was associated with worse cardiovascular health and early arterial injury among offspring in early adulthood. Evidence Rating Level: 2 (Good) Study Rundown: Adverse pregnancy outcomes (APOs) have been associated with long-term maternal cardiovascular health (CVH). However, research on the role of APOs in… ## [Resuscitative endovascular balloon occlusion of the aorta may not improve outcomes in adults with non-traumatic out-of-hospital cardiac arrest](https://www.2minutemedicine.com/resuscitative-endovascular-balloon-occlusion-of-the-aorta-may-not-improve-outcomes-in-adults-with-non-traumatic-out-of-hospital-cardiac-arrest/) _2026-05-14 · Alex Xiang · Cardiology | 2 Minute Medicine_ 1. Resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct to advanced life support (ALS) does not improve rates of return of spontaneous circulation (ROSC) in adult patients with non-traumatic out-of-hospital cardiac arrest (OHCA). Evidence Rating Level: 1 (Excellent) OHCA remains associated with extremely high mortality, with most patients not achieving ROSC, and \[…\] The… ## [Use of selective serotonin reuptake inhibitors guided by pharmacogenetic testing may improve treatment response in depression](https://www.2minutemedicine.com/use-of-selective-serotonin-reuptake-inhibitors-guided-by-pharmacogenetic-testing-may-improve-treatment-response-in-depression/) _2026-05-13 · Alex Xiang · Psychiatry | 2 Minute Medicine_ 1. Genotype-guided prescribing of selective serotonin reuptake inhibitors (SSRIs) may improve treatment response in children and adults with depression. Evidence Rating Level: 1 (Excellent) Although SSRIs are the most prescribed pharmacotherapy for depression, discontinuation rates remain high, with some studies reporting up to 50% discontinuation due to ineffectiveness or adverse effects.… ## [Maternal use of benzodiazepines and non-benzodiazepine hypnotics is not associated with increased risk of psychiatric](https://www.2minutemedicine.com/maternal-use-of-benzodiazepines-and-non-benzodiazepine-hypnotics-is-not-associated-with-increased-risk-of-psychiatric/) _2026-05-06 · Siwen Liu · Psychiatry | 2 Minute Medicine_ 1. Maternal use of benzodiazepines or non-benzodiazepine hypnotics (Z-hypnotics) during pregnancy was not associated with an increased risk of psychiatric disorders in offspring after controlling for shared familial factors. Evidence Rating Level: 2 (Good) Benzodiazepines and non-benzodiazepine hypnotics (Z-hypnotics) are frequently prescribed drugs among pregnant women who commonly experience… ## [A non-invasive neurostimulation intervention may improve social communication impairment in children with autism spectrum disorder](https://www.2minutemedicine.com/a-non-invasive-neurostimulation-intervention-may-improve-social-communication-impairment-in-children-with-autism-spectrum-disorder/) _2026-05-05 · Siwen Liu · Psychiatry | 2 Minute Medicine_ 1. Five days of accelerated continuous theta burst stimulation (a-cTBS) targeting the left primary motor cortex improved social communication impairment in children with autism spectrum disorder. Evidence Rating Level: 1 (Excellent) Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation technique that has shown efficacy in treating various neuropsychiatric… ## [Triple low-dose antihypertensive pill reduced recurrent stroke after intracerebral hemorrhage](https://www.2minutemedicine.com/triple-low-dose-antihypertensive-pill-reduced-recurrent-stroke-after-intracerebral-hemorrhage/) _2026-05-04 · Hannan Minhas · Cardiology | 2 Minute Medicine_ 1. In clinically stable patients with prior intracerebral hemorrhage, a fixed-dose combination pill containing three low-dose antihypertensive agents reduced recurrent stroke compared with placebo when added to standard care. 2. The triple pill also improved blood-pressure control and reduced major cardiovascular events, though treatment discontinuation due to adverse events was more common.… ## [WHO launches 2026 global initiative to bridge the schizophrenia mortality gap](https://www.2minutemedicine.com/who-launches-2026-global-initiative-to-bridge-the-schizophrenia-mortality-gap/) _2026-04-30 · Deepti Shroff · Psychiatry | 2 Minute Medicine_ 1. The World Health Organization has launched a global initiative to reduce the 15-to-20-year mortality gap for individuals with schizophrenia by 2030. 2. This effort prioritizes the integration of mandatory cardiovascular and metabolic screenings into psychiatric care to treat preventable physical conditions. The World Health Organization and Psychiatric Times have brought renewed attention this… ## [Invasive management for non-ST-segment elevation myocardial infarction in frail patients may not improve mortality](https://www.2minutemedicine.com/invasive-management-for-non-st-segment-elevation-myocardial-infarction-in-frail-patients-may-not-improve-mortality/) _2026-04-30 · Alex Xiang · Cardiology | 2 Minute Medicine_ 1. In frail, elderly patients with non-ST-segment elevation myocardial infarction (NSTEMI), invasive management with coronary angiography did not improve mortality and cardiovascular outcomes compared to conservative management. Evidence Rating Level: 1 (Excellent) Study Rundown: Frailty is becoming an increasingly important consideration in patient management as the global population continues to… ## [COVID-19 vaccination is associated with reduced risk of new-onset atrial fibrillation following COVID-19 infection](https://www.2minutemedicine.com/covid-19-vaccination-is-associated-with-reduced-risk-of-new-onset-atrial-fibrillation-following-covid-19-infection/) _2026-04-29 · Siwen Liu · Cardiology | 2 Minute Medicine_ 1. COVID-19 vaccination was associated with a reduced 24-month risk of new-onset atrial fibrillation/flutter after COVID-19 infection. Evidence Rating Level: 2 (Good) COVID-19 infection has been linked with cardiovascular complications such as new-onset atrial fibrillation/flutter (NOAF). While there is evidence of the COVID-19 vaccine being protective against the development of long COVID, its… ## [Polycythemia is not associated with increased mortality in heart failure](https://www.2minutemedicine.com/polycythemia-is-not-associated-with-increased-mortality-in-heart-failure/) _2026-04-28 · Siwen Liu · Cardiology | 2 Minute Medicine_ 1. Polycythemia was not associated with increased in-hospital, short-term, or long-term mortality. Evidence Rating Level: 2 (Good) Anemia has been consistently associated with worse outcomes in both chronic heart failure and acute decompensated HF (ADHF). Polycythemia has been linked to adverse outcomes in acute coronary syndrome (ACS), but whether a similar association exists for ADHF. \[…\] The…