Use of selective serotonin reuptake inhibitors guided by pharmacogenetic testing may improve treatment response in depression

1. Genotype-guided prescribing of selective serotonin reuptake inhibitors (SSRIs) may improve treatment response in children and adults with depression. Evidence Rating Level: 1 (Excellent) Although SSRIs are the most prescribed pharmacotherapy for depression, discontinuation rates remain high, with some studies reporting up to 50% discontinuation due to ineffectiveness or adverse effects.…