The Role of Butyrate in Gut Health, Immunity, and Neurocognitive Function: A Review (2026)

Abstract Butyrate , a short-chain fatty acid (SCFA) produced via bacterial fermentation of dietary fiber in the colon, has emerged as a critical modulator of gut health, immune regulation, and neurocognitive function. This review explores the metabolic, immunological, and neurological roles of butyrate, examining its mechanisms of action and implications for chronic disease prevention. Current…