Mechanisms of Vascular Acetylcholine Reactivity in Cardiac Hypertrophy: The Role of Calcium Channels and Endothelial PI3K/AKT/eNOS Signaling in Rats

Cardiac hypertrophy alters vascular function and promotes myocardial damage via oxidative stress and inflammation, with calcium channels and the PI3K/AKT/eNOS signalling pathway being pivotal in vascular reactivity. Nonetheless, their precise role in acetylcholine (ACh)-mediated vascular responses during hypertrophy remains little elucidated. The study aims to investigate calcium channel functions…