Histamine–DAO Axis in Migraine: Pathophysiology, Genetic Insights, Clinical Evidence, and Therapeutic Implications

Migraine is a common neurological illness marked by recurring headache episodes, followed by other neurological and gastrointestinal symptoms. While the precise pathophysiology of migraine is not fully elucidated, increasing evidence indicates that disruptions in histamine metabolism may significantly contribute to the onset of migraines. Diamine oxidase (DAO) is a crucial enzyme that facilitates…