Deep Sequencing Analysis of Mitochondrial DNA Heteroplasmy Transmission and the Genetic Bottleneck Effect in Mother-Daughter Pairs

The inheritance pattern of mitochondrial DNA (mtDNA) from mother to offspring is well known, but the dynamics of heteroplasmy, the coexistence of more than one type of mtDNA molecule per cell, as well as the influence of the Genetic Bottleneck on the Variant Allele Frequency (VAF), are still under active research investigation. This study was conducted with the objective of detecting and analyzing…