# in the pipeline (blogs) — RSS Amplifier Recent posts from the 2 feeds in the RSS Amplifier directory that cover in the pipeline. Page: Feed: --- ## [This generation isn’t growing up at local shopping centres like we did](https://shoppingcentrenews.com.au/partner-content/this-generation-isnt-growing-up-at-local-shopping-centres-like-we-did/) _2026-08-26 · Brett Farley of Auror · Shopping Centre News_ Shopping centres face larger public safety challenges beyond just typical retail theft at the stores within them. The post This generation isn’t growing up at local shopping centres like we did appeared first on Shopping Centre News . ## [Bunnings-anchored Adelaide LFR Centre sold to Charter Hall](https://shoppingcentrenews.com.au/latest-news/bunnings-anchored-adelaide-lfr-centre-sold-to-charter-hall/) _2026-08-26 · Thanh Nha · Shopping Centre News_ Located about 7km north of Adelaide CBD, the centre is anchored by a freestanding Bunnings Warehouse. The post Bunnings-anchored Adelaide LFR Centre sold to Charter Hall appeared first on Shopping Centre News . ## [Australian Retirement Trust buys half stake in Westfield Mt Gravatt](https://shoppingcentrenews.com.au/latest-news/australian-retirement-trust-buys-half-stake-in-westfield-mt-gravatt/) _2026-08-26 · Sean Cao · Shopping Centre News_ Scentre Group will continue to own 50 per cent of the shopping centre and will remain the property, leasing and development manager. The post Australian Retirement Trust buys half stake in Westfield Mt Gravatt appeared first on Shopping Centre News . ## [Aura Home + Life retail precinct opens on the Sunshine Coast](https://shoppingcentrenews.com.au/latest-news/aura-home-life-retail-precint-opens-on-the-sunshine-coast/) _2026-08-26 · My Nguyen · Shopping Centre News_ The precinct launched alongside several national retail brands, such as Rebel, The Good Guys, TK Maxx, and Pillow Talk. The post Aura Home + Life retail precinct opens on the Sunshine Coast appeared first on Shopping Centre News . ## [New projects boost Melbourne CBD retail vacancy rate, but other cities tighten](https://shoppingcentrenews.com.au/latest-news/new-projects-boost-melbourne-cbd-retail-vacancy-rate/) _2026-08-24 · Uyen Duong · Shopping Centre News_ The national increase was therefore mainly linked to new supply rather than a broad decline in leasing demand. The post New projects boost Melbourne CBD retail vacancy rate, but other cities tighten appeared first on Shopping Centre News . ## [Parkmore Shopping Centre unveils major retail precinct](https://shoppingcentrenews.com.au/latest-news/parkmore-shopping-centre-unveils-major-retail-precinct/) _2026-08-21 · My Nguyen · Shopping Centre News_ The new area is home to TK Maxx, Aldi, and Rebel, which together enhance Parkmore's standing as a shopping destination in Melbourne's southeast. The post Parkmore Shopping Centre unveils major retail precinct appeared first on Shopping Centre News . ## [Karalee Shopping Village sells for $76 million](https://shoppingcentrenews.com.au/latest-news/karalee-shopping-village-sells-for-76-million/) _2026-08-20 · My Nguyen · Shopping Centre News_ The unconditional transaction was negotiated at a yield of approximately 5.5 per cent, with final settlement scheduled for October this year. The post Karalee Shopping Village sells for $76 million appeared first on Shopping Centre News . ## [Beyond retail: Inside The District Docklands’ transformation](https://shoppingcentrenews.com.au/feature-stories/special-feature/beyond-retail-inside-the-district-docklands-transformation/) _2026-08-20 · Shopping Centre News · Shopping Centre News_ The District Docklands has spent the past five years reinventing itself around entertainment, dining and mixed-use activation. Jonathan Codman, Precinct Director, The District Docklands, shares the thinking behind the transformation and why entertainment has become the precinct’s new anchor. Over the past five years, the 10-hectare precinct on the edge of Melbourne’s CBD has undergone \[…\] The post… ## [$1bn eastern seaboard retail portfolio heads to market](https://shoppingcentrenews.com.au/latest-news/1bn-eastern-seaboard-retail-portfolio-heads-to-market/) _2026-08-19 · Sean Cao · Shopping Centre News_ The portfolio comprises eight high-performing retail assets across Sydney, Melbourne, Brisbane and the Gold Coast. The post $1bn eastern seaboard retail portfolio heads to market appeared first on Shopping Centre News . ## [Sydney LFR centre McGraths Hills Home sells for $66.8m](https://shoppingcentrenews.com.au/latest-news/industry-news/sydney-lfr-centre-mcgraths-hills-home-sells-for-66-8m/) _2026-08-19 · My Nguyen · Shopping Centre News_ The sale marks only the fourth LFR transaction completed in metropolitan Sydney over the past five years. The post Sydney LFR centre McGraths Hills Home sells for $66.8m appeared first on Shopping Centre News . ## [Real SIMs for AI Agents (Sponsored)](https://crawlproof.com/a/x9T0fFYGWmL5) _2026-08-19 · **Sponsored**_ Pass 2FA and verifications with real carrier numbers via our API. ## [Brisbane’s historic The Barracks set for a revamp](https://shoppingcentrenews.com.au/latest-news/brisbanes-historic-the-barracks-set-for-a-revamp/) _2026-08-19 · Uyen Duong · Shopping Centre News_ The Barracks has heritage value, character and a location near Brisbane’s CBD, but requires investment to increase activity and attract visitors beyond game days. The post Brisbane’s historic The Barracks set for a revamp appeared first on Shopping Centre News . ## [Repurposing for performance: Castle Towers’ next evolution](https://shoppingcentrenews.com.au/feature-stories/special-feature/repurposing-for-performance-castle-towers-next-evolution/) _2026-08-19 · Shopping Centre News · Shopping Centre News_ QIC is reimagining more than 20,000sqm of former department-store space at Castle Towers, transforming a traditional anchor tenancy into a curated retail precinct designed to meet changing customer expectations. Luke Young, General Manager – Leasing, explains how the strategy is reshaping the centre for the Hills community. Castle Towers has grown up with the Hills \[…\] The post Repurposing for… ## [Mintus buys Underwood Marketplace for $62.5 million](https://shoppingcentrenews.com.au/latest-news/mintus-buys-underwood-marketplace-for-62-5-million/) _2026-08-19 · Thanh Nha · Shopping Centre News_ The centre is anchored by Woolworths and Big W, and is home to 50 specialty tenancies including Priceline Pharmacy, Coffee Club, Domino’s and Australia Post. The post Mintus buys Underwood Marketplace for $62.5 million appeared first on Shopping Centre News . ## [Growing with the North-West: Rouse Hill Town Centre expands](https://shoppingcentrenews.com.au/feature-stories/special-feature/growing-with-the-north-west-rouse-hill-town-centre-expands/) _2026-08-19 · Shopping Centre News · Shopping Centre News_ GPT is investing over $200 million in the next stage of Rouse Hill Town Centre, adding more than 10,000sqm of retail, 50-plus new specialty stores and an enhanced Town Green. Anthony Iannuzzi, Head of Development, outlines how the expansion is keeping pace with Sydney’s rapidly growing North West. The approximately $200 million Stage 2 redevelopment \[…\] The post Growing with the North-West: Rouse… ## [Building a regional destination for the Sunshine Coast: Aura Town Centre takes shape](https://shoppingcentrenews.com.au/feature-stories/special-feature/building-a-regional-destination-for-the-sunshine-coast-aura-town-centre-takes-shape/) _2026-08-19 · Shopping Centre News · Shopping Centre News_ Stockland is bringing a new retail, dining and lifestyle destination to the heart of the rapidly growing Aura community on the Sunshine Coast. Marco Ettorre, Executive General Manager, Town Centres, shares how Aura Town Centre is being designed around everyday convenience, community connection and long-term growth. Stockland Aura Town Centre is a major new retail, \[…\] The post Building a regional… ## [Antler, Strand unveil ‘step change’ in new Adelaide concept store](https://shoppingcentrenews.com.au/latest-news/antler-strand-unveil-step-change-in-new-adelaide-concept-store/) _2026-08-19 · My Nguyen · Shopping Centre News_ The new concept adds to Strand’s network of more than 260 stores in Australia and New Zealand. The post Antler, Strand unveil ‘step change’ in new Adelaide concept store appeared first on Shopping Centre News . ## [OpenADMET: Response to Pat Walters](http://fbdd-lit.blogspot.com/2026/08/openadmet-response-to-pat-walters.html) _2026-08-04 · Peter Kenny · Molecular Design_ Pat Walters responded to my post on the OpenADMET initiative and I am responding to his post. As is normal for posts here my responses are italicised in red and enclosed in square brackets. Many thanks, Pat, for taking the time to respond to my comments. \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* A recent post on the Molecular Design blog by Peter Kenny critiques the OpenADMET initiative. While constructive… ## [The OpenADMET initiative](http://fbdd-lit.blogspot.com/2026/07/the-openadmet-initiative.html) _2026-07-27 · Peter Kenny · Molecular Design_ “Quantity has a quality all of its own” Original source unknown The quote with which I’ve opened the post on the OpenADMET initiative is often attributed to Joseph Stalin and some suggest that he might have been referring to the T-34. While the safety and comfort of crews were not priorities for Soviet tank designers the T-34 was a better tank than the quote might be taken to imply. In particular,… ## [The OpenBind initiative](http://fbdd-lit.blogspot.com/2026/06/the-openbind-initiative.html) _2026-06-22 · Peter Kenny · Molecular Design_ I’ll open the post on the OpenBind initiative with photos from my visit last year to Korea which was timed to coincide with the cherry blossoms (this meant that the customary April Fools post was from Seoul). Things did not start well on the day that I took these photos (having lined up the first shot for the day it became abundantly clear that the camera’s battery was still being charged at the… ## [Two new open data initiatives](http://fbdd-lit.blogspot.com/2026/06/two-new-open-data-initiatives.html) _2026-06-03 · Peter Kenny · Molecular Design_ I'll open the post with photos that I took in Seoul last year at the Dongdaemun Design Plaza ( DDP ) which was designed by Zaha Hadid (1950-2016) and I'm ashamed to admit to only having become aware of her ten years ago while wandering around the American University of Beirut (she studied mathematics at AUB and much later designed the building there that houses the Issam Fares Institute for Public… ## [Browse ThreatCrush Modules (Sponsored)](https://crawlproof.com/a/BoLInyKyK8s4) _2026-06-03 · **Sponsored**_ Install community-built security modules to extend real-time threat intelligence and monitoring ## [Grand Challenges for Predictive Modeling in Small Molecule Drug Discovery](http://fbdd-lit.blogspot.com/2026/05/grand-challenges-for-predictive.html) _2026-05-27 · Peter Kenny · Molecular Design_ In this blog post I’ll be taking a look at C2026 (Grand Challenges for Predictive Modeling in Small Molecule Drug Discovery) which has been published as a ChemXriv preprint. A well-organized collection of grand challenges can indeed help focus scientific research effort on the most important challenges and I consider C2026 to be welcome relief from the view that we can solve all problems with… ## [The objectives of drug design](http://fbdd-lit.blogspot.com/2026/05/the-objectives-of-drug-design.html) _2026-05-20 · Peter Kenny · Molecular Design_ I'll open the post on drug design objectives with photos from a most enjoyable and informative visit to the Australian Synchrotron early in 2010 when I was helping with fragment library design at CSIRO. I’ve been meaning for ages to do a post like this and was finally goaded into action when I recently looked at two short videos from interviews with Sir Demis Hassabis, founder of Google DeepMind… ## [Comparing ML models in small molecule drug discovery](http://fbdd-lit.blogspot.com/2026/04/comparing-ml-models-in-small-molecule.html) _2026-04-21 · Peter Kenny · Molecular Design_ To start the post I'll share a photo that I took in 2012 of incense sticks at the Truc Lam pagoda near Da Lat. Not long after taking this photo I lost a lens cap (although thankfully not the lens) riding a luge through a forest and would later visit a cricket farm (this was particularly welcome because I had developed a taste for fried crickets during a visit to Cambodia in 2005). I’ll be… ## [PAINS and Prejudice](http://fbdd-lit.blogspot.com/2026/04/pains-and-prejudice.html) _2026-04-01 · Peter Kenny · Molecular Design_ \<\< previous || next \>\> PAINS ( p an a ssay in terference compound s ) filters have exerted a hold over the drug discovery community ever since the BH2010 study appeared over 15 years ago. Initially I didn’t take much notice of PAINS filters and, in any case, I’d already moved on from analysis of high-throughput screening (HTS) output by that point (I might add ‘thankfully’ because looking at too… ## [Hit to Lead best practice?](http://fbdd-lit.blogspot.com/2026/01/hit-to-lead-best-practice.html) _2025-12-31 · Peter Kenny · Molecular Design_ I'm now in Trinidad and I'll share a 180° panorama from Paramin where I walk for exercise. This district in Trinidad's Northern Range is renowned for its agriculture and the most excellent produce is grown in 'gardens' on steep hillsides. My walk would take about two and a quarter hours if I just walked but it usually takes rather longer because I like to take photos and often stop on the ridge to… ## [Covalent ligand efficiency](http://fbdd-lit.blogspot.com/2025/11/covalent-ligand-efficiency.html) _2025-11-30 · Peter Kenny · Molecular Design_ It appears that whoever first described Economics as the ‘Dismal Science’ had never encountered a ligand efficiency metric. I’ll be taking a look at the FK2025 study (Covalent ligand efficiency) in this post and the study has already been reviewed by Dan. Something that I’ve observed repeatedly over the years is that authors of ligand efficiency studies exhibit a lack of understanding of units and… ## [Return to Flatland](http://fbdd-lit.blogspot.com/2025/08/return-to-flatland.html) _2025-08-05 · Peter Kenny · Molecular Design_ Whoever first referred to Economics as ‘The Dismal Science’ had clearly never read an article on ‘3Dness’ in drug discovery. My own experience reading articles on this topic is a sensation of having my life force slowly sucked out (I even suggested that reviewing the '3Dness' literature might be considered as an appropriate penance when I recently confessed my sins at St Gallen Cathedral) and the… ## [Assembling data sets for training ML bioactivity models](http://fbdd-lit.blogspot.com/2025/07/building-datasets-to-train-ml-models.html) _2025-07-06 · Peter Kenny · Molecular Design_ Here’s a photo from one of my exercise walks in Paramin and you can see the Caribbean Sea in the distance. This is perhaps my favourite view on the walk because it means that I’ve just got to the top of a particularly brutal hill (cars sometimes struggle to get to the top and on one occasion I watched a car fail miserably in four attempts) although you can’t always see the sea as clearly as in… ## [Property Forecast Index Validated](http://fbdd-lit.blogspot.com/2025/04/property-forecast-index-validated.html) _2025-03-31 · Peter Kenny · Molecular Design_ \<\< previous || next \>\> I arrived in Korea on Friday night and am greatly enjoying it here. Photos below show the Jungbu Dried Seafoods Market near where I'm staying and dinner on Sunday (spicy beef noodles). I visited the War Memorial on Sunday and took selfies with the Shenyang J-6 (Chinese version of MiG-19) 'liberated' by Capt. Lee Woong-pyeong when he defected to South Korea on 25th February… ## [Thinking About Aqueous Solvation](http://fbdd-lit.blogspot.com/2025/03/thinking-about-aqueous-solvation.html) _2025-03-09 · Peter Kenny · Molecular Design_ Given that it was International Women's Day yesterday, I'll open the the post (and blogging for 2025) with a photo of a gravestone at St James' Church in Bramley (Hampshire). In the current post I’ll be taking a look at some aspects of aqueous solvation and Richard Wolfenden’s 1983 “Waterlogged Molecules” article ( W1983 ) is still worth reading today (as an aside, Prof Wolfenden will turn ninety… ## [Trade Smarter With IBKR (Sponsored)](https://crawlproof.com/a/wH7Yj7P256wx) _2025-03-09 · **Sponsored**_ Join Interactive Brokers through a referral and start investing with low-cost global access. ## [Natural Intelligence?](http://fbdd-lit.blogspot.com/2024/12/natural-intelligence.html) _2024-12-31 · Peter Kenny · Molecular Design_ \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* My pulse will be quickenin' With each drop of strychnine We feed to a pigeon It just takes a smidgin To poison a pigeon in the park Tom Lehrer, Poisoning Pigeons in the Park | video \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* I’ll be reviewing the H2024 study (Occurrence of “Natural Selection in Successful Small Molecule Drug… ## [Assessment of AI-generated chemical structures using ML](http://fbdd-lit.blogspot.com/2024/10/assessment-of-ai-generated-chemical.html) _2024-10-20 · Peter Kenny · Molecular Design_ Previous \<\< || \>\> Next In an earlier post I considered what it might mean to describe drug design as AI-based. In this post I’ll take a general look at using machine learning (ML) to predict biological activity (and other pharmaceutically-relevant properties) for AI-generated chemical structures. Whether or not ML models ultimately prove to be fit for this purpose it is worth pointing out that… ## [Variability in biological activity measurements reported in the drug discovery literature](http://fbdd-lit.blogspot.com/2024/09/variability-in-biological-activity.html) _2024-09-18 · Peter Kenny · Molecular Design_ I'll open the post with a panorama from the summit of Shutlingsloe, sometimes referred to as Cheshire's Matterhorn, which at 506 m above sea level, is the third highest point in the county. When in the UK, I usually come here to mark the solstices and there's usually a good crowd here for the occasion (the winter solstice tends to be less well attended). The LR2024 study (Combining IC 50 or K i…