Variability in biological activity measurements reported in the drug discovery literature

I'll open the post with a panorama from the summit of Shutlingsloe, sometimes referred to as Cheshire's Matterhorn, which at 506 m above sea level, is the third highest point in the county. When in the UK, I usually come here to mark the solstices and there's usually a good crowd here for the occasion (the winter solstice tends to be less well attended). The LR2024 study (Combining IC 50 or K i…