Novel enzymes from a diffusion model (paper review)

Enzyme design is a bit of a grand challenge in protein science. Let’s just put it this way: enzymes have proven to be incredibly difficult to design effectively. Mayo and coworkers proposed an automated method for de novo enzyme design in 1997 , and more and more smart people have been dealing with the insane challenges posed by the problem of designing proficient catalysts ever since. In 2008,…