# endpoints age (audio feeds) — RSS Amplifier Recent posts from the 1 feeds in the RSS Amplifier directory that cover endpoints age. Page: Feed: --- ## [An Autopsy of Four Drugs: The Cause of Death for Four AstraZeneca and Novartis Oncology Programs](https://beyondtheslide.substack.com/p/an-autopsy-of-four-drugs-the-cause) _2026-08-14 · Dr. Luis Cano · Beyond the Slide_ Four Cases, One Broken Chain ## [When Target Expression Isn't Enough](https://beyondtheslide.substack.com/p/tumor-microenvironment-adc-blind-spot) _2026-08-07 · Dr. Luis Cano · Beyond the Slide_ The blind spot antibody-drug conjugates share with pathology AI ## [We Didn't Get Foundation Models Wrong. We Got the Question Wrong.](https://beyondtheslide.substack.com/p/we-didnt-get-foundation-models-wrong) _2026-07-31 · Dr. Luis Cano · Beyond the Slide_ Better perception alone won’t solve digital pathology’s standardization problem ## [The Relocation of Fragility : Innovation doesn't eliminate fragility. It redistributes it.](https://beyondtheslide.substack.com/p/the-relocation-of-fragility-innovation) _2026-07-24 · Dr. Luis Cano · Beyond the Slide_ THE MONTHLY REVIEW ## [THE COLD WAR OF DRUG DEVELOPMENT](https://beyondtheslide.substack.com/p/the-cold-war-of-drug-development) _2026-07-17 · Dr. Luis Cano · Beyond the Slide_ This isn't a war to be won. It's a race to not be the one left behind. ## [Healthcare Didn't Adapt to AI. AI Adapted to Healthcare.](https://beyondtheslide.substack.com/p/healthcare-didnt-adapt-to-ai-ai-adapted) _2026-07-10 · Dr. Luis Cano · Beyond the Slide_ Why disruptive technologies lose their transformative power when organizations force them into legacy frameworks. ## [The Sophistication Trap : Why More Technology Doesn’t Necessarily Create More Value](https://beyondtheslide.substack.com/p/the-sophistication-trap-why-more) _2026-07-03 · Dr. Luis Cano · Beyond the Slide_ The hospital had done the transition right. ## [Hacking the Medical System: How Necessity Drove Change But Not Adoption](https://beyondtheslide.substack.com/p/hacking-the-medical-system-how-necessity) _2026-06-26 · Dr. Luis Cano · Beyond the Slide_ How the industry built smarter algorithms when hospitals needed simpler systems and what happened when clinicians started fixing it themselves ## [The Proximity Paradox of Digital Pathology](https://beyondtheslide.substack.com/p/the-proximity-paradox-of-digital) _2026-06-19 · Dr. Luis Cano · Beyond the Slide_ How a technology designed to connect experts may be quietly weakening the invisible networks that make diagnosis possible. ## [The Most Expensive Experiment in Modern Biology](https://beyondtheslide.substack.com/p/the-most-expensive-experiment-in) _2026-06-12 · Dr. Luis Cano · Beyond the Slide_ How technology-first thinking destroys R&D programs before they begin ## [Web Coding With AI, Live (Sponsored)](https://crawlproof.com/a/sELNp23picRf) _2026-06-12 · **Sponsored**_ Collaborative screen sharing with simultaneous remote control, open source. ## [Is Pharma Ready for AI?, Or Has It Confused Investment with Capability?](https://beyondtheslide.substack.com/p/is-pharma-ready-for-ai-or-has-it) _2026-06-05 · Dr. Luis Cano · Beyond the Slide_ THE PROMISE : The biggest technology boom in the history of the pharmaceutical industry ## [The Problem Is Not the Model. It’s the Meeting After the Model.](https://beyondtheslide.substack.com/p/the-problem-is-not-the-model-its) _2026-05-29 · Dr. Luis Cano · Beyond the Slide_ AI is already producing useful predictions, what organizations still don’t know how to produce are decisions ## [The Translation Gap](https://beyondtheslide.substack.com/p/the-translation-gap) _2026-05-22 · Dr. Luis Cano · Beyond the Slide_ Why modern biomedical organizations generate biological intelligence faster than they can operationalize it ## [The Domestication of Medical AI: How Europe selects which forms of clinical intelligence get to survive](https://beyondtheslide.substack.com/p/the-domestication-of-medical-ai-how) _2026-05-15 · Dr. Luis Cano · Beyond the Slide_ Earlier this year, physicians across the UK and EU opened their laptops to find that OpenEvidence, a clinical AI platform used by more than 40% of doctors across 10,000 US hospitals, had gone dark overnight. ## [From Photograph to Video, The New Science of Measuring Disease: Rethinking Endpoints in the Age of AI (Part 4)](https://beyondtheslide.substack.com/p/from-photograph-to-video-the-new) _2026-05-08 · Dr. Luis Cano · Beyond the Slide_ In the first article of this series, we corrected a misunderstanding: the FDA did not approve an AI-based endpoint. ## [The Gold Standard Was Made of Clay. Why Histology Was Never Enough. Rethinking Endpoints in the Age of AI (Part 3b)](https://beyondtheslide.substack.com/p/the-gold-standard-was-made-of-clay) _2026-05-01 · Dr. Luis Cano · Beyond the Slide_ In the previous chapter of this series, we explored the gap between what evidence promises and what patients experience. ## [The Trial Says It Works. Your Patient Disagrees: Rethinking Endpoints in the Age of AI (Part 3)](https://beyondtheslide.substack.com/p/the-trial-says-it-works-your-patient) _2026-04-24 · Dr. Luis Cano · Beyond the Slide_ In the previous chapter, we left a question unanswered. ## [Beyond the Loop: AI as an Extension of Clinical Reasoning](https://beyondtheslide.substack.com/p/beyond-the-loop-ai-as-an-extension) _2026-04-10 · Dr. Luis Cano · Beyond the Slide_ If the problem wasn’t a lack of supervision, the solution can’t be more supervision either. ## [The Illusion of Control: Why "Human in the Loop" Is Clinical AI's Biggest Regulatory Fiction](https://beyondtheslide.substack.com/p/the-illusion-of-control-why-human) _2026-04-03 · Dr. Luis Cano · Beyond the Slide_ This is a detour from my series on endpoints and digital pathology but this topic keeps generating questions I can't ignore: where are we actually going, and how? ## [Trade Bitcoin & Ethereum (Sponsored)](https://crawlproof.com/a/WE3QYp2D1ct7) _2026-04-03 · **Sponsored**_ Buy, sell and margin trade BTC & ETH with fiat currencies ## [An Endpoint Is Not a Biomarker, and That Difference Can Kill a Drug : Rethinking Endpoints in the Age of AI (Part 2)](https://beyondtheslide.substack.com/p/an-endpoint-is-not-a-biomarker-and) _2026-03-27 · Dr. Luis Cano · Beyond the Slide_ In the previous chapter, we looked at a case that generated considerable noise in the community: the supposed “approval of an AI-based endpoint.”