# dyno — RSS Amplifier Recent posts from the 2 feeds in the RSS Amplifier directory that cover dyno. Page: Feed: --- ## [Genetic medicine is about to be transformed by the agent economy](https://dynotx.substack.com/p/genetic-medicine-is-about-to-be-transformed) _2026-06-23 · Dyno Therapeutics · Dyno Therapeutics_ The modular nature of genetic medicine is particularly suitable for agentic work. ## [Painted Zipp](https://robot-daycare.com/posts/painted_zipp/) _2026-06-20 · Home on Robot Daycare_ I finished applying all the layers of paint, sparkles, and clearcoat to the Zipp 2001 frame a couple months ago, and finally worked up the motivation to sand and polish the clearcoat. I did 2 coats of dark grey base coat, 2 coats of the Keirin flake topcoat, and probably 5+ coats of the clear topcoat so I’d have enough meat to sand down the high spots and polish without hitting the sparkles… ## [Drafting Table: an engineering sketchbook](https://robot-daycare.com/posts/drafting_table/) _2026-05-26 · Home on Robot Daycare_ I got a Wacom MovinkPad 11 drawing tablet a few months ago as a portable replacement for my ancient Wacom Bamboo USB drawing tablet. Overall it’s been great. I’ve been using it for illustrating blog posts and making engineering sketches for work and personal projects. I’ve enjoyed Clip Studio for actual “art”, but haven’t found a program I like as an engineering… ## [Low-profile two-piece vises for the CNC router](https://robot-daycare.com/posts/mod_vise/) _2026-04-20 · Home on Robot Daycare_ I replaced the little 5-axis mill with a router recently, and needed a low-profile vise system for holding large workpieces. I’ve heard good things about the SMW Mod Vise, but they are designed for fixture plates, not 100mm pitch t-slots like the router has. And 3 sets to cover the hole table with serrated inserts would be pretty pricey. I came up with a simple design that uses these… ## [Good Bonds](https://robot-daycare.com/posts/adhesive/) _2026-04-15 · Home on Robot Daycare_ Adhesive bonds. Don’t worry, this isn’t becoming a finance blog. I do a lot of bonding parts together between my work and personal projects. At this point I have some (I think) reasonable default choices - Loctite 401 or 380 for plastics and elastomers, Loctite E-20HP or 3M DP420 for rigid metal & composites, Loctite 648 for metal slip/press fits, etc. But for important or unusual… ## [Claude Mythos Preview matches the best humans in solving Dyno’s sequence design challenge](https://dynotx.substack.com/p/claude-mythos-preview-matches-the) _2026-04-10 · Dyno Therapeutics · Dyno Therapeutics_ At Dyno, we believe the future of biology will be shaped by AI systems that can reason about sequence, structure, and function at once to ultimately help design therapies with precision in vivo. For a decade, we’ve had a front seat in seeing how our ability to model and test new sequence designs has improved. Biological sequence models have become far more sophisticated since we started working on… ## [Dyno Psi-Phi: Shaping new futures for protein design](https://dynotx.substack.com/p/dyno-psi-phi-shaping-new-futures) _2026-03-18 · Dyno Therapeutics · Dyno Therapeutics_ The promise of doing protein design with AI models is to do in one shot on a computer what would take months or even years of trial and error in the lab. ## [Electric motor scaling laws and inertia in robot actuators](https://robot-daycare.com/posts/actuation_series_1/) _2026-03-12 · Home on Robot Daycare_ This is the beginning of a series of posts about robot actuation. The intent here is not to prescribe some specific architecture or solution, but to talk about the fundamentals, with as little bias as I can manage. Hopefully you learn something. Here’s an ostensibly straightforward question for anyone who’s spent time thinking about robot actuators. Take a look at the three cartoon… ## [Machining new endcaps for a DT Swiss hub](https://robot-daycare.com/posts/making_dt_hub_endcaps/) _2026-03-02 · Home on Robot Daycare_ I needed to convert a DT Swiss hub from using a 15mm thru-axle down to a 12mm thru axle to fit on my commuter bike. You can buy the parts to do this, but instead of spending $50 on the parts, I spent some quality time with the lathe and a log of 7075 to make a new set. ## [Machining a saddle clamp for the Zipp](https://robot-daycare.com/posts/zipp_saddle_clamp/) _2026-02-17 · Home on Robot Daycare_ The original saddle clamps on the Zipp 2001’s were not very well designed, and the clamp that came with my frame (like many) was broken. The originals have 2 major problems: 1) The screws that clamp the rails on the saddle are tightened counterclockwise, not clockwise - I’ve seen stripped out screws because of this on a couple clamps. You think you’re loosening the saddle clamps,… ## [Open directory of blogs (Sponsored)](https://crawlproof.com/a/mCN2RixQ1ufh) _2026-02-17 · **Sponsored**_ Drop URLs or OPML — get per-blog pages plus machine-readable JSON, OPML, text ## [Zipp 2001 Restoration, Part 1](https://robot-daycare.com/posts/zipp-2001-restoration-part-1/) _2026-02-11 · Home on Robot Daycare_ I think the Zipp 2001 is one of the coolest bicycles ever made. These were only produced from 1992-1997, until the UCI banned bikes that weren’t the traditional “double-diamond” shape from professional racing. Probably because they were too fast. Image taken from this 1993 Zipp Catalog The early 90’s was when frame builders started seriously using carbon fiber for its… ## [Cultivating an ecosystem of trust through principled decision-making](https://dynotx.substack.com/p/cultivating-an-ecosystem-of-trust) _2026-01-20 · Tyson Bertmaring · Dyno Therapeutics_ How Dyno’s unconventional partnership success principles cultivate an ecosystem of trust for gene therapy developers ## [A new toolpost spindle, part 1](https://robot-daycare.com/posts/2026-01-16-a-new-toolpost-spindle-part-1/) _2026-01-16 · Home on Robot Daycare_       3D printed expanding fixture for op 2    ## [Can AI agents solve the “last mile” problem in generative therapeutic design?](https://dynotx.substack.com/p/can-ai-agents-solve-the-last-mile) _2025-11-11 · David Levy-Booth · Dyno Therapeutics_ How agentic AI systems, aligned with the goal of curing genetic disease, can accelerate genetic agency ## [Kart Rear Brake Mounting](https://robot-daycare.com/posts/2025-10-05-kart-rear-brake-mounting/) _2025-10-05 · Home on Robot Daycare_  Split rear axle means 2 rear brakes Laser cut stainless steel bracket from Send Cut Send Using the lathe as a drill press to countersink the holesRe-using the old brake rotor Time for some plumbing ## [And We're Back](https://robot-daycare.com/posts/2025-09-01-and-we-re-back/) _2025-09-01 · Home on Robot Daycare_ It has been an eventful year.  I'm finally back to working on projects. After some firmware fiddling, the new drive units are finally spinning, driven by the kart's original gen 2 Prius-based inverter: ## [A year of adventures](https://robot-daycare.com/posts/2025-07-16-a-year-of-adventures/) _2025-07-16 · Home on Robot Daycare_ This isn't one of my usual project blog posts, but I owe my dear readers some context for the lack of project content. The last year did not go like I expected. Part 1: I ride my bike a lot In mid May last year my friend Sam and I decided to ride the Great Divide Mountain Bike Route, a mostly off-road route from Banff, AB to the Mexico border in Antelope Wells, NM.  We'd been talking about it… ## [A Computational LEAP over an In vivo Experiment](https://dynotx.substack.com/p/a-computational-leap-over-an-in-vivo) _2024-12-17 · Dyno Therapeutics · Dyno Therapeutics_ As 2024 comes to a close, I look back at one of Dyno’s most exciting technical developments. ## [Drive Units Mounted](https://robot-daycare.com/posts/2024-12-09-drive-units-mounted/) _2024-12-09 · Home on Robot Daycare_ ## [Drive unit mounting parts](https://robot-daycare.com/posts/2024-11-17-drive-unit-mounting-parts/) _2024-11-17 · Home on Robot Daycare_ All bonded together A torsion-less bar, if you will ## [Collect Open Source Legends (Sponsored)](https://crawlproof.com/a/zUnCSb958Buj) _2024-11-17 · **Sponsored**_ Open-licensed art, limited foil trading packs, and optional on-chain mints. ## [Kart Steering Yoke](https://robot-daycare.com/posts/2024-11-10-kart-steering-yoke/) _2024-11-10 · Home on Robot Daycare_ A fun afternoon design project: Grip geometry still  needs some fine-tuning ## [Go Kart Revival Part 1: Drive Units](https://robot-daycare.com/posts/2024-10-31-go-kart-revival-part-1-drive-units/) _2024-10-31 · Home on Robot Daycare_  As I've mentioned in previous posts, robot land has an annual car-and-other-vehicle show.  Last year I brought the trike, but the year before that I brought the electric kart I worked on with Bayley. Picture from Bayley Before the event, the kart hadn't been touched since the pre-Covid days.  Bringing it back to life and ripping around the parking lot was a great reminder of two… ## [Working on the kart again](https://robot-daycare.com/posts/2024-10-19-working-on-the-kart-again/) _2024-10-19 · Home on Robot Daycare_  Finally retrieved it from MITERS, where it's been hanging from the ceiling for the last six years or so Prius inverter based motor drive will be the next thing to be redone after it drives again: ## [Off on an adventure](https://robot-daycare.com/posts/2024-09-24-off-on-an-adventure/) _2024-09-24 · Home on Robot Daycare_ Why haven't I been building anything?  I was off on an Adventure.