Sensing Unfolded Proteins

Do cells take joy in tidying? Absolutely! But how can they tell where the messes are? Any household knows that without cleaning and disposal, nothing else is possible. Things pile up, messes accumulate, everything comes to a standstill. Cells are the same, needing a constant flow of new materials in, trash out, recycling, and cleanups. One of the major kinds of mess in cells is unfolded proteins,…