Age-Related Changes in Metabolism that Contribute to Inflammatory Microglia in the Brain

In recent years, an increasing level of attention has been given to microglia as an important contribution to neurodegeneration in the aging brain. Microglia are innate immune cells resident in the central nervous system, analogous to the macrophages found elsewhere in the body. They are deeply involved in the complex processes of normal tissue function and maintenance, not just a defense against…