Phototoxic Dermatitis Induced by Doxycycline and Plant-Derived Furocoumarins: Different Mechanisms, Shared Clinical Consequences

Abstract Phototoxic dermatitis is a non-immunologic inflammatory reaction that occurs when photosensitizing substances interact with ultraviolet A (UV-A) radiation. It differs fundamentally from an allergic drug reaction, which is immune-mediated and may present with life-threatening symptoms such as airway swelling, difficulty breathing, or generalized urticaria requiring immediate medical…