Fiber-Seq: Plasmids Model Chromosomes Well

A recent publication in Molecular Cell involving Fiber-Seq caught my attention, though I've since discovered this preprinted over a year ago. One of the challenges in exploring the effects of genetic variations is the cost & effort to generate collections of variation which can be profiled by available methods. This paper explores using Fiber-Seq on transfected plasmids and finds that, with…