# cognitive decline (blogs) — RSS Amplifier Recent posts from the 6 feeds in the RSS Amplifier directory that cover cognitive decline. Page: Feed: --- ## [Cancer Therapies That May Be Ineffective—or Harmful - Part 2](https://paulmarik.substack.com/p/cancer-therapies-that-may-be-ineffectiveor) _2026-08-20 · Cancer & Metabolic Healing · Paul Marik_ Choose your Healer Carefully ## [Brain-predicted age difference may reliably predict dementia progression](https://www.2minutemedicine.com/brain-predicted-age-difference-may-reliably-predict-dementia-progression/) _2026-08-19 · Paary Balakumar · Neurology | 2 Minute Medicine_ 1. Brain-predicted age difference (brain-PAD) is a robust, reproducible predictor of dementia progression across two independent estimation methods, and it is most clinically useful in subjective cognitive decline, where it can help identify low-risk patients and reassure the “worried well,” rather than in mild cognitive impairment, where visual rating scales already capture most prognostically… ## [Diffusion-weighted imaging may aid in prognostication for intracerebral hemorrhage](https://www.2minutemedicine.com/diffusion-weighted-imaging-may-aid-in-prognostication-for-intracerebral-hemorrhage/) _2026-08-18 · Paary Balakumar · Neurology | 2 Minute Medicine_ 1. Diffusion-weighted imaging (DWI)-positive lesions are common after intracerebral hemorrhage (ICH) and serve as an independent biomarker of cerebral small vessel disease (cSVD) severity and worse 6-month functional outcome, supporting their potential use in prognostication and clinical trial patient selection. 2. The anatomical distribution of DWI-positive lesions may help distinguish cerebral… ## [Unproven Cancer Treatments: Separating Hope From Evidence - Part 1](https://paulmarik.substack.com/p/unproven-cancer-treatments-separating) _2026-08-18 · Cancer & Metabolic Healing · Paul Marik_ Choose your Healer Carefully ## [A neurostimulation intervention may improve pain in patients with chronic low back pain](https://www.2minutemedicine.com/a-neurostimulation-intervention-may-improve-pain-in-patients-with-chronic-low-back-pain/) _2026-08-17 · Paary Balakumar · Neurology | 2 Minute Medicine_ 1. Restorative neurostimulation produces durable, clinically meaningful improvements in pain, disability, and quality of life at 5 years in real-world chronic mechanical low back pain patients. Evidence Rating Level: 3 (Average) This 5-year follow-up study evaluated restorative neurostimulation (ReActiv8) for chronic mechanical low back pain (CLBP) attributed to multifidus dysfunction. Restorative… ## [Cancer Is Not Defeated by a Single Target: Why Metabolic Flexibility Demands Multi-Target Therapy](https://paulmarik.substack.com/p/cancer-is-not-defeated-by-a-single) _2026-08-17 · Cancer & Metabolic Healing · Paul Marik_ Cancer Is Not Defeated by a Single Target: Why Metabolic Flexibility Demands Multi-Target Therapy ## [MYC: The Master Driver of Cancer Growth](https://paulmarik.substack.com/p/myc-the-master-driver-of-cancer-growth) _2026-08-15 · Cancer & Metabolic Healing · Paul Marik_ Among the thousands of genes implicated in cancer, few have had as profound an impact as MYC. Unlike many oncogenes that drive a limited number of tumors, MYC acts as a universal amplifier of malignant behavior. It regulates cellular proliferation, metabolism, protein synthesis, mitochondrial function, stemness, angiogenesis, immune evasion, and genomic instability. Estimates suggest that… ## [TP53: The Guardian of the Genome](https://paulmarik.substack.com/p/tp53-the-guardian-of-the-genome) _2026-08-14 · Cancer & Metabolic Healing · Paul Marik_ Why the World's Most Important Tumor Suppressor Does Far More Than Prevent DNA Mutations ## [APC and the Origins of Colorectal Cancer](https://paulmarik.substack.com/p/apc-and-the-origins-of-colorectal) _2026-08-12 · Cancer & Metabolic Healing · Paul Marik_ How One Broken Gene Opens the Door to Cancer ## [EGFR: The First Great Targeted Therapy](https://paulmarik.substack.com/p/egfr-the-first-great-targeted-therapy) _2026-08-11 · Cancer & Metabolic Healing · Paul Marik_ How a Single Mutation Changed the Way We Think About Cancer ## [One OS for your AI workforce (Sponsored)](https://crawlproof.com/a/u8SIS3vOli6k) _2026-08-11 · **Sponsored**_ Build, direct, and supervise an AI workforce from a single operating workspace. ## [What is the KRAS Mutation – and Why does it Matter?](https://paulmarik.substack.com/p/what-is-the-kras-mutation-and-why) _2026-08-09 · Cancer & Metabolic Healing · Paul Marik_ A KRAS G12V mutation is one of the most common activating mutations in the KRAS oncogene. It results from a single amino acid substitution in which glycine (G) at codon 12 is replaced by valine (V). This seemingly small change has profound biological consequences because it locks the KRAS protein into an “on” state, continuously stimulating pathways that drive cancer cell growth, survival,… ## [Antithrombotic agents may be effective in preventing migraine in patients with patent foramen ovale](https://www.2minutemedicine.com/antithrombotic-agents-may-be-effective-in-preventing-migraine-in-patients-with-patent-foramen-ovale/) _2026-08-07 · Siwen Liu · Neurology | 2 Minute Medicine_ 1. The antithrombotic agents aspirin, clopidogrel, and rivaroxaban were non-inferior to metoprolol for responder rate in participants with patent foramen ovale and migraine. Evidence Rating Level: 1 (Excellent) Patent foramen ovale (PFO) has been associated with migraine and has been suggested to involve a microembolic mechanism. Antithrombotic treatment has been proposed for migraine prevention… ## [Understanding the BRAF Mutation: One of Oncology’s Biggest Success Stories](https://paulmarik.substack.com/p/understanding-the-braf-mutation-one) _2026-08-07 · Cancer & Metabolic Healing · Paul Marik_ The BRAF mutation is one of the best-characterized cancer-driving (oncogenic) mutations. ## [BRCA1 and BRCA2: Beyond Breast Cancer](https://paulmarik.substack.com/p/brca1-and-brca2-beyond-breast-cancer) _2026-08-06 · Cancer & Metabolic Healing · Paul Marik_ Why These Mutations Are Really About DNA Repair, Genomic Stability, and Precision Oncology ## [Hematologic inflammatory indices may predict prognosis in younger patients with COVID-19 but not older patients](https://www.2minutemedicine.com/hematologic-inflammatory-indices-may-predict-prognosis-in-younger-patients-with-covid-19-but-not-older-patients/) _2026-08-04 · Siwen Liu · Infectious Disease | 2 Minute Medicine_ 1. Hematologic inflammatory indices in emergency department patients with COVID-19 showed an age-dependent prognostic performance for 30-day mortality, with systemic immune-inflammation index showing good discriminatory performance in patients \<65 years and poorer performance in patients \>65 years. Evidence Rating Level: 2 (Good) Hematologic markers derived from the complete blood count (CBC)… ## [Which Comes First: Driver Mutations or the Warburg Effect?](https://paulmarik.substack.com/p/which-comes-first-driver-mutations) _2026-08-04 · Cancer & Metabolic Healing · Paul Marik_ This question lies at the heart of one of the most important debates in modern cancer biology. ## [New Mexico measles outbreak associated with significant costs](https://www.2minutemedicine.com/new-mexico-measles-outbreak-associated-with-significant-costs/) _2026-08-02 · Adrian Wong · Infectious Disease | 2 Minute Medicine_ 1. In this cost analysis, the 2025 measles outbreak in New Mexico was estimated to impose a societal economic burden of $5.4 million, equivalent to approximately $53,500 per case. 2. Public health response activities accounted for the majority of costs, with more than $2 million devoted to vaccination-related efforts aimed at controlling the outbreak. Evidence \[…\] The post New Mexico measles… ## [A digital mental health intervention may improve anxiety in breast cancer survivors](https://www.2minutemedicine.com/a-digital-mental-health-intervention-may-improve-anxiety-in-breast-cancer-survivors/) _2026-07-31 · Lori Lai · Psychiatry | 2 Minute Medicine_ 1. Among a large cohort of breast cancer survivors, those who participated in digital mental health treatment reported a reduction in symptoms of anxiety, with additional human coaching associated with a reduction in depression. Evidence Rating Level: 1 (Excellent) Almost 50% of all women suffering from advanced breast cancer experience significant anxiety and depression within \[…\] The post A… ## [Praziquantel (Biltricide) is associated with higher cure rate than albendazole (Zentel) in the treatment of clonorchiasis](https://www.2minutemedicine.com/praziquantel-biltricide-is-associated-with-higher-cure-rate-than-albendazole-zentel-in-the-treatment-of-clonorchiasis/) _2026-07-31 · Alex Xiang · Infectious Disease | 2 Minute Medicine_ 1. In the treatment of Clonorchis sinensis, albendazole (Zentel) demonstrates a high egg reduction rate but a significantly lower cure rate compared to praziquantel (Biltricide). Evidence Rating Level: 1 (Excellent) Study Rundown: Clonorchiasis is caused by infection with Clonorchis sinensis, a helminth parasite, and can lead to significant morbidities, including cholelithiasis, cholangitis,… ## [A cognitive rehabilitation program may improve cognitive performance in patients with long COVID](https://www.2minutemedicine.com/a-cognitive-rehabilitation-program-may-improve-cognitive-performance-in-patients-with-long-covid/) _2026-07-28 · Lori Lai · Psychiatry | 2 Minute Medicine_ 1. In a multicenter, single-blind, randomized clinical trial, participation in a cognitive rehabilitation program improved goal attainment and cognitive test scores in patients suffering from Long COVID-related cognitive dysfunction. Evidence Rating Level: 1 (Excellent) Long COVID is defined as a chronic condition that occurs following the infection of COVID-19, present for at least 3 months \[…\]… ## [Make any domain metal (Sponsored)](https://crawlproof.com/a/0YaApijofb9F) _2026-07-28 · **Sponsored**_ Turn any domain into a blacked-out metal landing page with an email waitlist ## [Medical or procedural abortion may not increase risk of psychotropic medication use after five years](https://www.2minutemedicine.com/medical-or-procedural-abortion-may-not-increase-risk-of-psychotropic-medication-use-after-five-years/) _2026-07-27 · Lori Lai · Psychiatry | 2 Minute Medicine_ 1. Among a Danish population-based cohort study, increased initiation of psychotropic medication in the first year following both medical and procedural methods of abortion were found, with decreased risk of initiation of psychotropic medication within five or more years following both medical and procedural abortions. Evidence Rating Level: 2 (Good) There is limited research on \[…\] The post… ## [Epidural analgesia in labour is not associated with adverse neonatal health outcomes](https://www.2minutemedicine.com/epidural-analgesia-in-labour-is-not-associated-with-adverse-neonatal-health-outcomes/) _2026-07-23 · Simon Pan · Neurology | 2 Minute Medicine_ 1. Epidural analgesia in labour is not associated with significant risk of neonatal neurological morbidity, neonatal morbidity or mortality. Evidence Rating Level: 2 (Good) Epidural analgesia during labour is regarded as the most effective form of pain control, which is important given that poor pain control may lead to physiological stress in mothers with important \[…\] The post Epidural analgesia… ## [Cefazolin non-inferior to penicillins for methicillin-susceptible Staphylococcus aureus bacteremia](https://www.2minutemedicine.com/cefazolin-non-inferior-to-penicillins-for-methicillin-susceptible-staphylococcus-aureus-bacteremia/) _2026-07-23 · Zhenyu Li · Infectious Disease | 2 Minute Medicine_ 1. In this international randomized controlled trial of adults with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, cefazolin was noninferior to antistaphylococcal penicillins for 90-day mortality. 2. Cefazolin was also associated with fewer adverse events, particularly lower rates of acute kidney injury and treatment discontinuation due to toxicity. Evidence Rating Level: 1… ## [Novel antifungal shows promise for patients with refractory disseminated coccidioidomycosis](https://www.2minutemedicine.com/novel-antifungal-shows-promise-for-patients-with-refractory-disseminated-coccidioidomycosis/) _2026-07-20 · Adrian Wong · Infectious Disease | 2 Minute Medicine_ 1. In this single-group, open-label trial, olorofim was associated with a complete or partial clinical response in over 75% of patients with disseminated coccidioidomycosis (DCM) and limited or no treatment options. 2. Clinical success rates were highest among patients without central nervous system (CNS) infection. Evidence Rating Level: 2 (Good) Study Rundown: Every year, thousands \[…\] The post… ## [A chemical denervation intervention may be safe and effective for pain management in avascular necrosis of the hip](https://www.2minutemedicine.com/a-chemical-denervation-intervention-may-be-safe-and-effective-for-pain-management-in-avascular-necrosis-of-the-hip/) _2026-07-16 · Paary Balakumar · Neurology | 2 Minute Medicine_ 1. Chemical neurolysis of the anterior hip capsular branches appears to be a safe and effective analgesic option for AVN-related hip pain refractory to conservative management, with durable benefit in a subset of patients through 6 months. Evidence Rating Level: 3 (Average) Avascular necrosis (AVN) of the hip frequently causes refractory pain that persists despite \[…\] The post A chemical… ## [Spinal instability may be the primary cause of pain in sacral metastases as opposed to neurologic compromise](https://www.2minutemedicine.com/spinal-instability-may-be-the-primary-cause-of-pain-in-sacral-metastases-as-opposed-to-neurologic-compromise/) _2026-07-14 · Paary Balakumar · Neurology | 2 Minute Medicine_ 1. Although neurological symptoms (motor deficits, sensory impairment) were more frequent in patients with sitting-related sacral pain on univariate comparison, this association did not hold in multivariable analysis (aOR 0.83, 95% CI 0.21–2.95, p=0.780), indicating spinal instability—not neurological compromise—was the primary driver of this pain. 2. Patients with sitting-related sacral pain had… ## [Infection risk with infliximab (Remicade) and adalimumab (Humira) is similar in pediatric inflammatory bowel disease](https://www.2minutemedicine.com/infection-risk-with-infliximab-remicade-and-adalimumab-humira-is-similar-in-pediatric-inflammatory-bowel-disease/) _2026-07-14 · Siwen Liu · Infectious Disease | 2 Minute Medicine_ 1. Among children with inflammatory bowel disease, there were no significant differences in serious or outpatient infection risk between initiating infliximab (Remicade) and adalimumab (Humira). Evidence Rating Level: 2 (Good) Study Rundown: Pediatric Inflammatory Bowel Disease (IBD) includes Crohn disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U), and its prevalence is… ## [Chronic Wasting Disease Spreads Silently in Symptom-Free Animals, Raising Questions About Long-Term Human Risk](https://www.2minutemedicine.com/chronic-wasting-disease-spreads-silently-in-symptom-free-animals-raising-questions-about-long-term-human-risk/) _2026-07-14 · Deepti Shroff · Infectious Disease | 2 Minute Medicine_ 1. A University of Calgary study published in Science Advances this month found that chronic wasting disease can spread silently in animals with no clinical symptoms, and demonstrated limited but detectable cross-species prion transmission in nonhuman primate models. 2. There are no confirmed human cases, but the expanding geographic footprint of the disease in wild \[…\] The post Chronic Wasting… ## [Glucosamine Linked to Faster Alzheimer’s Progression in Patients with Mild Cognitive Impairment](https://www.2minutemedicine.com/glucosamine-linked-to-faster-alzheimers-progression-in-patients-with-mild-cognitive-impairment/) _2026-07-10 · Deepti Shroff · Psychiatry | 2 Minute Medicine_ 1. University of Florida researchers found that glucosamine, the popular joint supplement taken by tens of millions of older Americans, is associated with a 25% higher likelihood of progressing from mild cognitive impairment to Alzheimer’s disease. 2. The proposed mechanism is biochemically plausible: glucosamine is a sugar-related molecule that crosses the blood-brain barrier and appears \[…\] The… ## [I'm joining The 81 Collection](https://fulghum.io/81-collection) _2026-07-06 · Jordan Fulghum_ Bringing software and AI leverage into durable, necessary businesses. ## [Ultra-Quiet Business Mini (Sponsored)](https://crawlproof.com/a/jBgdkFVWkvxw) _2026-07-05 · **Sponsored**_ Compact business mini, ultra-quiet for focused work. ## [Dietary habits are associated with dementia risk in patients with Alzheimer’s pathology](https://www.2minutemedicine.com/dietary-habits-are-associated-with-dementia-risk-in-patients-with-alzheimers-pathology/) _2026-07-03 · Siwen Liu · Neurology | 2 Minute Medicine_ 1. Greater adherence to a dietary pattern with lower inflammatory potential was associated with lower dementia risk among individuals with Alzheimer’s pathology and broader neurobiological risk. Evidence Rating Level: 2 (Good) Alzheimer’s disease (AD) is a leading cause of dementia. Evidence suggests that nutrients, foods, and dietary patterns may mitigate AD. However, it is unclear \[…\] The post… ## [localhost is disappearing](https://fulghum.io/local.html) _2026-06-30 · Jordan Fulghum_ Why localhost is becoming the wrong default for agentic software development. ## [Concomitant COVID-19 and influenza vaccination not linked to increased adverse events](https://www.2minutemedicine.com/concomitant-covid-19-and-influenza-vaccination-not-linked-to-increased-adverse-events/) _2026-06-29 · Adrian Wong · Infectious Disease | 2 Minute Medicine_ 1. In this target trial emulation, same-day administration of COVID-19 and influenza vaccines was not associated with an increased risk of adverse events. 2. No differences in adverse event risk were observed across the bivalent, XBB-adapted, and KP-adapted COVID-19 vaccine formulations. Evidence Rating Level: 2 (Good) Study Rundown: The evolution of SARS-CoV-2 has led to \[…\] The post Concomitant… ## [Cruise ship hantavirus outbreak turns into a global contact tracing test](https://www.2minutemedicine.com/cruise-ship-hantavirus-outbreak-turns-into-a-global-contact-tracing-test/) _2026-06-24 · Deepti Shroff · Infectious Disease | 2 Minute Medicine_ 1. An Andes virus outbreak aboard the MV Hondius expedition cruise ship led to severe respiratory illness, multiple deaths, and contact tracing across 32 countries. 2. The episode is clinically important because Andes virus is the only hantavirus with documented person-to-person transmission, although it does not behave like a highly transmissible airborne pathogen. The Andes \[…\] The post Cruise… ## [Recombinant Zoster Vaccination May Reduce Dementia Risk in Older Adults](https://www.2minutemedicine.com/recombinant-zoster-vaccination-may-reduce-dementia-risk-in-older-adults/) _2026-06-15 · Adrian Wong · Neurology | 2 Minute Medicine_ 1. In this target trial emulation, receipt of the recombinant zoster vaccine (RZV) was associated with a reduced risk of dementia among older adults admitted to skilled nursing facilities. 2. The association was more pronounced among women and among individuals who had not previously received the live attenuated herpes zoster vaccine. Evidence Rating Level: 2 \[…\] The post Recombinant Zoster… ## [I built a private ChatGPT for my family](https://fulghum.io/family-chatgpt) _2026-06-15 · Jordan Fulghum_ A local LLM, a family vault, and one tiny computer with a ridiculous GPU hanging off it. ## [OpenAI has a branding problem](https://fulghum.io/openai) _2026-06-03 · Jordan Fulghum_ The company that led the consumer AI race might be losing the naming one. ## [A novel therapy targeting γ-aminobutyric acid is safe and may be effective in major depressive disorder](https://www.2minutemedicine.com/a-novel-therapy-targeting-%ce%b3-aminobutyric-acid-is-safe-and-may-be-effective-in-major-depressive-disorder/) _2026-05-27 · Alex Xiang · Psychiatry | 2 Minute Medicine_ 1. H3-10353, a novel γ-aminobutyric acid (GABA) positive allosteric modulator, is safe and well-tolerated in healthy patients and those with major depressive disorder (MDD), and demonstrated some therapeutic benefits in a phase 1 clinical trial. Evidence Rating Level: 1 (Excellent) Although there are numerous classes of medications for depression, these treatments result in remission in \[…\] The… ## [Selective serotonin reuptake inhibitors may reduce risk of total joint arthroplasty in osteoarthritis](https://www.2minutemedicine.com/selective-serotonin-reuptake-inhibitors-may-reduce-risk-of-total-joint-arthroplasty-in-osteoarthritis/) _2026-05-21 · Paary Balakumar · Psychiatry | 2 Minute Medicine_ 1. Initiation of centrally acting analgesics in patients with osteoarthritis (OA) was associated with a higher long-term risk of total joint arthroplasty compared with SSRI initiation. 2. Management of comorbid depression may play an important role in OA symptom progression and surgical outcomes, potentially exceeding the benefit of centrally mediated analgesic effects alone. Evidence Rating \[…\]… ## [Post-primary-care](https://fulghum.io/post-primary-care) _2026-05-21 · Jordan Fulghum_ The clinical default is usually necessity instead of upside. Their question is, “Do you need this to treat a condition?” not “Would this actually improve your odds of staying healthy, strong, and functional for the next thirty years?” ## [Use of selective serotonin reuptake inhibitors guided by pharmacogenetic testing may improve treatment response in depression](https://www.2minutemedicine.com/use-of-selective-serotonin-reuptake-inhibitors-guided-by-pharmacogenetic-testing-may-improve-treatment-response-in-depression/) _2026-05-13 · Alex Xiang · Psychiatry | 2 Minute Medicine_ 1. Genotype-guided prescribing of selective serotonin reuptake inhibitors (SSRIs) may improve treatment response in children and adults with depression. Evidence Rating Level: 1 (Excellent) Although SSRIs are the most prescribed pharmacotherapy for depression, discontinuation rates remain high, with some studies reporting up to 50% discontinuation due to ineffectiveness or adverse effects.… ## [Maternal use of benzodiazepines and non-benzodiazepine hypnotics is not associated with increased risk of psychiatric](https://www.2minutemedicine.com/maternal-use-of-benzodiazepines-and-non-benzodiazepine-hypnotics-is-not-associated-with-increased-risk-of-psychiatric/) _2026-05-06 · Siwen Liu · Psychiatry | 2 Minute Medicine_ 1. Maternal use of benzodiazepines or non-benzodiazepine hypnotics (Z-hypnotics) during pregnancy was not associated with an increased risk of psychiatric disorders in offspring after controlling for shared familial factors. Evidence Rating Level: 2 (Good) Benzodiazepines and non-benzodiazepine hypnotics (Z-hypnotics) are frequently prescribed drugs among pregnant women who commonly experience… ## [A non-invasive neurostimulation intervention may improve social communication impairment in children with autism spectrum disorder](https://www.2minutemedicine.com/a-non-invasive-neurostimulation-intervention-may-improve-social-communication-impairment-in-children-with-autism-spectrum-disorder/) _2026-05-05 · Siwen Liu · Psychiatry | 2 Minute Medicine_ 1. Five days of accelerated continuous theta burst stimulation (a-cTBS) targeting the left primary motor cortex improved social communication impairment in children with autism spectrum disorder. Evidence Rating Level: 1 (Excellent) Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation technique that has shown efficacy in treating various neuropsychiatric… ## [WHO launches 2026 global initiative to bridge the schizophrenia mortality gap](https://www.2minutemedicine.com/who-launches-2026-global-initiative-to-bridge-the-schizophrenia-mortality-gap/) _2026-04-30 · Deepti Shroff · Psychiatry | 2 Minute Medicine_ 1. The World Health Organization has launched a global initiative to reduce the 15-to-20-year mortality gap for individuals with schizophrenia by 2030. 2. This effort prioritizes the integration of mandatory cardiovascular and metabolic screenings into psychiatric care to treat preventable physical conditions. The World Health Organization and Psychiatric Times have brought renewed attention this… ## [On Mystery](https://fulghum.io/mystery) _2026-03-26 · Jordan Fulghum_ The difference between answers you receive and answers you have to build together. ## [I Used Claude Code + Autoresearch to Trace My Family History Back to Jamestown](https://fulghum.io/genealogy) _2026-03-20 · Jordan Fulghum_ From fewer than 10 names to 168 individuals, 19+ family lines, and 300+ years of sourced history. ## [POST-SOFTWARE (March 2026)](https://fulghum.io/POST-SOFTWARE) _2026-03-04 · Jordan Fulghum_ LANGUAGE \> CODE ## [Your Product Is No Longer the Center of Gravity](https://fulghum.io/gravity) _2026-02-25 · Jordan Fulghum_ AI is inverting the traditional product development cycle in B2B software. ## [Remote Work, AI, and the Disappearing Engineer](https://fulghum.io/meaning) _2026-02-16 · Jordan Fulghum_ What happens when you're shipping more than ever and feeling less than ever? ## [Mastery Fun vs Frontier Fun](https://fulghum.io/fun2) _2026-01-06 · Jordan Fulghum_ Understanding the difference between two kinds of fun, and how coding agents change the game for each.