What is the KRAS Mutation – and Why does it Matter?

A KRAS G12V mutation is one of the most common activating mutations in the KRAS oncogene. It results from a single amino acid substitution in which glycine (G) at codon 12 is replaced by valine (V). This seemingly small change has profound biological consequences because it locks the KRAS protein into an “on” state, continuously stimulating pathways that drive cancer cell growth, survival,…