# cognitive decline (audio feeds) — RSS Amplifier Recent posts from the 2 feeds in the RSS Amplifier directory that cover cognitive decline. Page: Feed: --- ## [The Christchurch Mutation: What the Science Investigation Actually Found](https://braintrials.substack.com/p/one-patient-changed-alzheimers-research) _2026-08-19 · Jose-Alberto Palma MD PhD · Brain Trials_ A Colombian woman with a double mutation escaped genetic AD for decades. A Science investigation questions how that case became a larger group, a startup antibody and an AAV gene therapy. ## [Jim Kwik: Your Brain Has a Savings Account. You're Probably Draining It.](https://neuroathletics.substack.com/p/jim-kwik-your-brain-has-a-savings) _2026-08-12 · Louisa Nicola · Neuro Athletics_ Answers from the worlds leading Brain Coach for elite athletes [Listen](https://api.substack.com/feed/podcast/210912522/e463eab7987e4b987c7ab8a98da0576b.mp3) ## [Is Fibromyalgia Genetic? What the New 2.5-Million-Person Study Found](https://braintrials.substack.com/p/no-scientists-did-not-prove-fibromyalgia) _2026-08-11 · Jose-Alberto Palma MD PhD · Brain Trials_ A Nature Medicine study of 2.5 million people found 26 genetic risk variants for fibromyalgia — including the Huntington's disease gene (HTT). Then it answered questions its data couldn't support. ## [This Billionaire is Obsessed with his Health](https://neuroathletics.substack.com/p/this-billionaire-is-obsessed-with) _2026-08-05 · Louisa Nicola · Neuro Athletics_ He tracks his VO2 max, his sleep, and just about every health metric known. Most of it you and I will never do. But one thing he does costs nothing, and it may predict how long you'll live. [Listen](https://api.substack.com/feed/podcast/209922442/d18c8a933747585ebeb5d823af724d5c.mp3) ## [Anatomy of a Failed Trial](https://braintrials.substack.com/p/anatomy-of-a-failed-trial) _2026-08-04 · Jose-Alberto Palma MD PhD · Brain Trials_ "Failed" has at least eight meanings, and the differences among them are everything. A working guide to reading a negative trial — and why only one kind of failure tells you the science was wrong. ## [The 100-Year-Olds Whose Brains Were Full of Alzheimer's. And Who Kept Their Minds Anyway.](https://neuroathletics.substack.com/p/the-100-year-olds-whose-brains-were) _2026-07-31 · Louisa Nicola · Neuro Athletics_ Scientists just found the exact moment a brain decides whether Alzheimer's pathology becomes Alzheimer's disease. ## [The World's Top Brain Surgeon Takes Zero Supplements](https://neuroathletics.substack.com/p/the-worlds-top-brain-surgeon-takes) _2026-07-29 · Louisa Nicola · Neuro Athletics_ He has operated on more than 10,000 brains. I asked him what he does to protect his own. His answer surprised me. [Listen](https://api.substack.com/feed/podcast/207071405/152114ac6f4c7fc81a2e82d9c65449b8.mp3) ## [Vagus Nerve Hacks: What the Evidence Actually Says](https://braintrials.substack.com/p/your-vagus-nerve-does-not-need-hacking) _2026-07-25 · Jose-Alberto Palma MD PhD · Brain Trials_ Cold plunges, humming, gargling, ear-clip "vagus nerve stimulation": what actually reaches the nerve, what the real (FDA-approved) devices do, and why the nerve was never the problem. ## [Menopause Is Not a Reproductive Event](https://neuroathletics.substack.com/p/menopause-is-not-a-reproductive-event) _2026-07-22 · Louisa Nicola · Neuro Athletics_ The same hormone therapy that protects a woman at 45 appears to harm her at 68. I made an episode about why. [Listen](https://api.substack.com/feed/podcast/207056224/bf9ee3e488464fbc9bd857cc141da5d4.mp3) ## [CELIA: The Dose-Response Was in the Side Effects](https://braintrials.substack.com/p/diranersen-lowered-tau-why-did-the) _2026-07-21 · Jose-Alberto Palma MD PhD · Brain Trials_ Biogen's tau ASO hit its biomarkers and missed its primary at AAIC — and the clinical signal was largest at the lowest dose. The safety explains why. ## [Save with community-voted codes (Sponsored)](https://crawlproof.com/a/qU7ERodfU18J) _2026-07-21 · **Sponsored**_ Search thousands of community-verified coupon codes — 100% free, no account needed. ## [Sponsor TNE](https://neuroathletics.substack.com/p/sponsor-tne) _2026-07-19 · Louisa Nicola · Neuro Athletics_ To get in touch, please fill out this short form ## [Inside the Farm Growing Food With No Soil, No Sun, and No Pesticides](https://neuroathletics.substack.com/p/inside-the-farm-growing-food-with) _2026-07-14 · Louisa Nicola · Neuro Athletics_ Why a neuroscientist spent an afternoon in a robotic farm in Arizona. [Listen](https://api.substack.com/feed/podcast/207015819/f7eaf3cb7c4a8c5242fa9884b67c70ff.mp3) ## [Never Get Alzheimer's: The Supplement Stack That Actually Has Evidence](https://neuroathletics.substack.com/p/never-get-alzheimers-the-supplement) _2026-07-13 · Louisa Nicola · Neuro Athletics_ Most brain supplement advice ignores one finding: these nutrients only work together. Here is what the trials actually show. ## [The Nail That Wasn't There](https://braintrials.substack.com/p/the-nail-that-wasnt-there) _2026-07-11 · Jose-Alberto Palma MD PhD · Brain Trials_ The body doesn't wait to find out what's real. It acts on what it expects - and sometimes what it expects is wrong. ## [Can Walking Prevent Alzheimer's? A New Study on "Super Movers" Says How Fast Matters](https://neuroathletics.substack.com/p/can-walking-prevent-alzheimers-a-224) _2026-07-09 · Louisa Nicola · Neuro Athletics_ A new study in Neurology tracked nearly 4,000 older adults and found the fastest walkers in their 80s were 50% less likely to develop cognitive decline. ## [This Drug Was Illegal For 50 Years. Now It's Rewriting Neuroscience.](https://neuroathletics.substack.com/p/illegaldrug) _2026-07-07 · Louisa Nicola · Neuro Athletics_ This is the most research-dense episode I’ve ever recorded. [Listen](https://api.substack.com/feed/podcast/204738154/fee494a649fe9b89b9f482154fd7d2db.mp3) ## [Four AAIC Readouts, One Real Topline: How to Tell New Data From a Well-Dressed Update](https://braintrials.substack.com/p/the-aaic-2026-readouts-worth-watching) _2026-07-07 · Jose-Alberto Palma MD PhD · Brain Trials_ Four programs, one genuine topline, and a lesson in telling a first-time readout apart from a well-dressed update. ## [Why We Faint](https://braintrials.substack.com/p/why-we-faint) _2026-07-01 · Jose-Alberto Palma MD PhD · Brain Trials_ The first time I fainted, I was a medical student dissecting a vagus nerve. What happened in my body that day was older than humans — and it had nothing to do with me being weak. ## [1,021 Drug Trials Used Wearables. The FDA Has Formally Qualified Zero Sensor-Derived Endpoints](https://braintrials.substack.com/p/wearables-have-been-in-1021-drug) _2026-06-27 · Jose-Alberto Palma MD PhD · Brain Trials_ The digital biomarker field has spent two decades building more sensitive instruments. The FDA keeps asking a different question entirely. ## [Your Fitness Tracker Is Accurate About Two Things. Everything Else Depends on Algorithms.](https://braintrials.substack.com/p/your-fitness-tracker-is-accurate) _2026-06-24 · Jose-Alberto Palma MD PhD · Brain Trials_ A Stanford sleep-lab test and the scientific literature reveal which wearable claims are well validated—and which remain mostly educated guesses. ## [AI publishing with human taste (Sponsored)](https://crawlproof.com/a/ahUSwUsN6kEQ) _2026-06-24 · **Sponsored**_ Convert AI research into blogs, podcasts, and newsletters with optional human review. ## [How Many Steps Do You Really Need to Prevent Dementia?](https://braintrials.substack.com/p/how-many-steps-do-you-really-need) _2026-06-20 · Jose-Alberto Palma MD PhD · Brain Trials_ The number 10,000 came from a 1960s Japanese pedometer ad. The number 9,826 came from a single observational study that can't prove what the headlines claim. Here's what the evidence actually supports ## [When the Biomarker Says Stop but the Company Says Go](https://braintrials.substack.com/p/when-the-biomarker-says-stop-and) _2026-06-16 · Jose-Alberto Palma MD PhD · Brain Trials_ Two Parkinson's drugs moved their key biomarkers in the wrong direction. Both companies reframed the result as confirmatory. One program has already failed. The other is still running. ## [When Hitting the Target Isn't Enough: What LUMA Tells Us About Parkinson's Drug Development](https://braintrials.substack.com/p/biogens-lrrk2-inhibitor-failed-in) _2026-06-07 · Jose-Alberto Palma MD PhD · Brain Trials_ BIIB122 missed every endpoint despite \>90% peripheral kinase inhibition. The reasons matter for the LRRK2 hypothesis, for the Ionis ASO that worked better, and for where PD drug development goes next ## [Why You Wake Up at 3 AM After Drinking — and Why It Happens Even If You Don't](https://braintrials.substack.com/p/why-you-wake-up-at-3-am-after-drinking) _2026-06-02 · Jose-Alberto Palma MD PhD · Brain Trials_ It's not random. As alcohol clears, five biological systems snap back at once; and the same machinery wakes the people who never touched a drink. ## [Diranersen Missed Its Primary Endpoint. Biogen is Going to Phase 3 Anyway.](https://braintrials.substack.com/p/the-first-tau-drug-to-move-biomarkers) _2026-05-26 · Jose-Alberto Palma MD PhD · Brain Trials_ Biogen's tau-targeting ASO slowed AD cognitive decline "comparable to approved amyloid-targeting therapies." But the trial was halved mid-enrollment and no actual numbers have been released. ## [No, Scientists Did Not Find the Optimal Amount of Sleep](https://braintrials.substack.com/p/no-scientists-did-not-find-the-optimal) _2026-05-22 · Jose-Alberto Palma MD PhD · Brain Trials_ A Nature paper claims your brain ages fastest at 6.42 hours. The entire finding rests on one subjective survey question — answered in whole hours. ## [Short Note: When A Meta-Analysis Answers the Wrong Question](https://braintrials.substack.com/p/short-note-when-a-meta-analysis-answers) _2026-04-17 · Jose-Alberto Palma MD PhD · Brain Trials_ A Recent Meta-Analysis Concludes Amyloid-Targeted Therapies Offer Little Clinical Benefit in Alzheimer’s Disease. The Analysis Has Critical Limitations. ## [Deep Dive: Stem Cell Therapies for Parkinson's: Where the Field is Moving](https://braintrials.substack.com/p/deep-dive-dopaminergic-cell-therapy) _2026-03-06 · Jose-Alberto Palma MD PhD · Brain Trials_ Two Nature papers last year, a recent approval in Japan, and the unanswered question of whether neuron replacement will truly change PD ## [Short Note: Stopping Alzheimer’s Drugs Early Costs Cognition: Real-World French Data](https://braintrials.substack.com/p/short-note-stopping-symptomatic-alzheimers) _2026-02-23 · Jose-Alberto Palma MD PhD · Brain Trials_ A nationwide natural experiment using clinical trial emulation shows that discontinuing cholinesterase inhibitors accelerates cognitive decline in Alzheimer’s patients ## [Short Note: A 10-Minute IV Psychedelic (DMT) for Depression — Rapid Signal, Small Study](https://braintrials.substack.com/p/short-note-a-10-minute-iv-psychedelic) _2026-02-20 · Jose-Alberto Palma MD PhD · Brain Trials_ A single short infusion produced a large antidepressant effect at 2 weeks. The biology is intriguing. The bar remains high. ## [Stop CI/CD & Supply-Chain Attacks (Sponsored)](https://crawlproof.com/a/gysCRLjU5oqU) _2026-02-20 · **Sponsored**_ Per-PR: 17 CI/CD checks and package malware scans with inline Check Run findings. ## [Essay: Who Owns Your Autonomic Nervous System?](https://braintrials.substack.com/p/essay-who-owns-your-autonomic-nervous) _2026-02-15 · Jose-Alberto Palma MD PhD · Brain Trials_ Big tech is building continuous physiological telemetry. Emotional certainty is another matter.