22 Best Anti Aging Supplements that Work (2026): 1000+ Studies Analyzed and Ranked

Medically Reviewed by: OneDayMD Editorial Team | Written by: Dr Frank Yap, MD | Last Updated: August 2026 Quick Answer The anti-aging supplements with the strongest human evidence are vitamin D3 (with K2 and magnesium), omega-3 fatty acids, creatine, glycine, and collagen peptides — each backed by large randomized trials tied to biological aging, mortality, or a specific hallmark of aging.…