Data-driven construction of an imine reductase library capable of broad-scope reductive amination at equimolar substrate concentrations

Nature Communications, Published online: 22 August 2026; doi:10.1038/s41467-026-76869-7 Reductive amination catalysed by imine reductases and reductive aminases is a powerful method for the asymmetric synthesis of chiral amines, yet the generality and practical limitations of these enzymes remain poorly understood. Here, the authors combine large-scale, iterative activity screening, sequence…