Association of polymorphic markers Arg753Gln in the <i>TLR2</i> Gene, T-1237C and G2848A in the <i>TLR9</i> Gene with the risk of developing primary adrenal insufficiency in individuals living in the Moscow Region of the Russian Federation

Background. Primary adrenal insufficiency (PAI) is an endocrine disorder caused by the gradual destruction of all three layers of the adrenal cortex and characterized by insufficient secretion of cortisol and aldosterone. This condition significantly reduces patients’ quality of life, making its timely diagnosis crucial. Autoimmune disorders are the etiological factor in approximately 80% of PAI…