Adenocarcinoma in Situ of the Cervix

Introduction Adenocarcinoma in situ (AIS) of the cervix is a precursor to invasive adenocarcinoma but behaves differently from squamous precancer. Its endocervical location, multifocality, and potential for skip lesions make detection and complete excision challenging. AIS is human papillomavirus (HPV) related and may coexist with squamous dysplasia. It is most strongly associated with high-risk…