Selective serotonin reuptake inhibitors may reduce risk of total joint arthroplasty in osteoarthritis

1. Initiation of centrally acting analgesics in patients with osteoarthritis (OA) was associated with a higher long-term risk of total joint arthroplasty compared with SSRI initiation. 2. Management of comorbid depression may play an important role in OA symptom progression and surgical outcomes, potentially exceeding the benefit of centrally mediated analgesic effects alone. Evidence Rating […]…