Our journey through low-complexity regions

Those who inspect SVs often have probably noticed many SVs fall in low-complexity regions (LCRs) or tandem repeats and they are challenging to call. How many and how challenging? I could not find a good answer in the literature, so I decided to work with Qian (Alvin) Qin to measure by ourselves. To start with, we need to identify LCRs in the human genome. This turned out to be a non-trivial…