Antithrombotic agents may be effective in preventing migraine in patients with patent foramen ovale

1. The antithrombotic agents aspirin, clopidogrel, and rivaroxaban were non-inferior to metoprolol for responder rate in participants with patent foramen ovale and migraine. Evidence Rating Level: 1 (Excellent) Patent foramen ovale (PFO) has been associated with migraine and has been suggested to involve a microembolic mechanism. Antithrombotic treatment has been proposed for migraine prevention…