Really hard questions: trials, real-world evidence, and patient values. Archimedes April 2026

When is a trial not a trial? Can you make a big dataset work as if it was randomised? Can we really use real-world evidence rather than trial evidence for clinical decision-making? Read here: https://adc.bmj.com/content/111/4/373.2 The hardest decisions are those where the answer is truly complex, evolving and really involves an understanding of patient values and attitudes. This is a…